CIENCIASMEDICASNEWS: Medical News | Medical Articles: Speed Up Your Workflows and Brighten Up Your Drug Discovery Lab

jueves, 6 de junio de 2019

Medical News | Medical Articles: Speed Up Your Workflows and Brighten Up Your Drug Discovery Lab

	June 6, 2019
	Drug Discovery and Production
	The latest drug discovery news from News Medical

Speed Up Your Workflows and Brighten Up Your Drug Discovery Lab

Help INTEGRA learn about your pipetting needs for drug discovery research by completing a short questionnaire by 14th June 2019, for the opportunity to win their most popular serological pipettor: The PIPETBOY. There are 100 available to win from the limited edition range in colours Pink Sunrise, Agave and Ocean Dream.

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Streamlined workflow for fragment based screening by NMR

NMR binding assays are routinely applied for hit finding and validation during the early stages of drug discovery, particularly for fragment-based lead generation. Weak binding affinities in the μM to mM range are a hallmark of fragments that are valuable starting points for medicinal chemistry development programs. This webinar (taking place 18th June), describes automated screening and analysis methods available for the detection of binding fragments.

Pipettes of the Future: Automation for Acceleration

The successful development of current life-saving therapeutics often starts with the identification of new drug targets using sophisticated instrumentation, bioinformatics, and highly valuable human tissue samples. Hypotheses are rigorously tested, experimental conditions tightly controlled, and increasingly complex data sets meticulously analyzed. This vital step in the research discovery process is critically dependent on the consistent and precise preparation, and handling, of these samples, together with often costly reagents.

	New natural product fractions library to advance drug discovery efforts $New natural product fractions library to advance drug discovery efforts$ SP Scientific’s Genevac Series 3 HT-12 Centrifugal Evaporator has been cited in a recently published paper by the Natural Products Support Group, Leidos Biomedical Research, Inc. and the Frederick National Laboratory for Cancer Research as an important sample preparation tool in their extraction and pre-fractionation work to create a new natural product fractions library.

	Scientists 'on the right track' toward universal flu vaccine A research study into influenza virus transmission has offered new insights into the antibodies and immune responses that may protect against the influenza virus. The research could bring scientists a step closer to developing an effective, universal flu vaccine.

	Are fruit fly 'avatars' the next step in personalized medicine? Researchers have created fruit fly “avatars” that have helped to guide treatment for a man who had terminal colon cancer. The team genetically engineered flies that had the same mutations as the man’s tumor and then tested different drug combinations to see which ones kept the flies alive. Doctors eventually settled on a drug combination that was the most effective and administered it to the man.

	Hit to Lead (H2L) Process in Drug Discovery As the name suggests, the hit to lead (H2L) stage of drug discovery which aims to discover compounds of interest (leads) from a selection of compounds (hits) that demonstrate promising therapeutic effects. The hit to lead process, which is also referred to as lead generation, typically occurs following the completion of target validation, assay development, and high-throughput screening studies.