Relationship between TGF-β1 + 869 T/C and + 915 G/C gene polymorphism and risk of acute rejection in renal transplantation recipients | BMC Medical Genetics | Full Text

Relationship between TGF-β1 + 869 T/C and + 915 G/C gene polymorphism and risk of acute rejection in renal transplantation recipients | BMC Medical Genetics | Full Text



BMC Medical Genetics

Relationship between TGF-β1 + 869 T/C and + 915 G/C gene polymorphism and risk of acute rejection in renal transplantation recipients

• Hong-Yan Li,
• Tianbiao ZhouEmail author,
• Shujun Lin and
• Wenshan LinView ORCID ID profile

BMC Medical Genetics201920:113

https://doi.org/10.1186/s12881-019-0847-2

©  The Author(s). 2019

• Received: 27 November 2018
• Accepted: 10 June 2019
• Published: 25 June 2019

Open Peer Review reports

Abstract

Background

This meta-analysis was conducted to assess the relationship between the transforming growth factor-beta 1 (TGF-β1) + 869 T/C gene polymorphism, + 915 G/C gene polymorphism, and the susceptibility of acute rejection in the recipients with renal transplantation.

Methods

Relevant studies were searched and identified from the Cochrane Library and PubMed, and eligible investigations were recruited and data were calculated by meta-analysis.

Results

In this study, we found no relationship between either TGF-β1 + 869 T/C or TGF-β1 + 915 G/C gene polymorphism and acute rejection susceptibility in patients with renal transplantation. No association between either gene polymorphism and acute rejection susceptibility in patients with renal transplantation in Caucasian, Asian, or African populations individually was found.

Conclusion

The TGF-β1 + 869 T/C and + 915 G/C gene polymorphisms are not associated with acute rejection susceptibility in recipients with renal transplantation.

Keywords

• Acute rejection
• Renal transplantation
• TGF-β1
• Polymorphisms
• Meta-analysis