Epidemiology and etiology of Traveler’s diarrhea in Bangkok, Thailand, a case-control study

Ladaporn BodhidattaEmail author View ORCID ID profile,
Sinn Anuras,
Siriporn Sornsakrin,
Umaporn Suksawad,
Oralak Serichantalergs,
Apichai Srijan,
Orntipa Sethabutr and
Carl J. Mason

Tropical Diseases, Travel Medicine and Vaccines20195:9

https://doi.org/10.1186/s40794-019-0085-9

Received: 18 February 2019
Accepted: 9 May 2019
Published: 7 June 2019

Abstract

Background

Traveler’s diarrhea (TD) is a common health problem among visitors from developed to developing countries. Although global and regional estimates of pathogen distribution are available, the etiology of diarrhea among non-military travelers to Thailand is largely unknown.

Methods

A prospective TD case-control study was conducted among adult travelers from developed countries at a prominent hospital in Bangkok, Thailand during 2001–2003. Stool samples were collected from acute TD cases and non-diarrheal controls and analyzed for bacterial, viral, and protozoan pathogens by microbiology, ELISA or PCR methods. Calculation of adjusted odd ratios for risk factors was performed by logistic regression using STATA statistical software.

Results

Stool samples were collected and analyzed from 389 TD cases and 400 non-diarrhea controls. At least one pathogen was detected in 227 (58%) cases and 124 (31%) controls. Plesiomonas (14%), Vibrio (14%), Campylobacter (14%), and norovirus (12%) were the most frequently isolated pathogens among cases and significantly associated with diarrhea at p = 0.006, p < 0.001, p < 0.001, p < 0.001, respectively. Shigella (3%) and ETEC (8%), detected in lower prevalence, also showed significant association with TD at p < 0.001 and p = 0.002, respectively. Travelers from East Asian countries had an increased risk of Vibrio infection (Crude odds ratio: 3.1, p-value = 0.001); travelers from the United States, Canada, and Europe had an increased risk of Campylobacterinfection (Crude odds ratio: 2.6, p-value = 0.001); and travelers from Australia and New Zealand had an increased risk of Salmonella infection (Crude odds ratio: 3.2, p-value = 0.009).

Conclusions

Etiology of TD in Thailand is mainly of bacterial origin. Plesiomonas, Vibrio,and norovirus are underappreciated diarrheagenic pathogens. In our study, the origin of the traveler plays an important role in diarrhea etiology. Understanding variations in TD severity and etiology among travelers from different regions warrants further study.