Emerging leaders in biological engineering

Emerging leaders in biological engineering

Over the past decade, biological engineering has promoted the convergence of themes from multiple disciplines and has gained significant promise in integrating the principles of biology and engineering methodologies to address grand challenges in human health and the health of the planet. This thematic series highlights exciting new areas and emerging leaders who are addressing many of these challenges.

Edited by Raj R Rao

Click here for an Editorial highlighting the thematic series.

1. Content Type:Review

   Quantum dot therapeutics: a new class of radical therapies

   Traditional therapeutics and vaccines represent the bedrock of modern medicine, where isolated biochemical molecules or designed proteins have led to success in treating and preventing diseases. However, sever...

   Authors:Max Levy, Partha P. Chowdhury and Prashant Nagpal

   Citation:Journal of Biological Engineering 2019 13:48

   Published on: 29 May 2019

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2. Content Type:Review

   Non-canonical amino acid labeling in proteomics and biotechnology

   Metabolic labeling of proteins with non-canonical amino acids (ncAAs) provides unique bioorthogonal chemical groups during de novo synthesis by taking advantage of both endogenous and heterologous protein synt...

   Authors:Aya M. Saleh, Kristen M. Wilding, Sarah Calve, Bradley C. Bundy and Tamara L. Kinzer-Ursem

   Citation:Journal of Biological Engineering 2019 13:43

   Published on: 22 May 2019

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3. Content Type:Review

   Genetic circuits to engineer tissues with alternative functions

   Persistent and complex problems arising with respect to human physiology and pathology have led to intense investigation into therapies and tools that permit more targeted outcomes and biomimetic responses to ...

   Authors:C. P. Healy and T. L. Deans

   Citation:Journal of Biological Engineering 2019 13:39

   Published on: 3 May 2019

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4. Content Type:Review

   Electrical energy storage with engineered biological systems

   The availability of renewable energy technologies is increasing dramatically across the globe thanks to their growing maturity. However, large scale electrical energy storage and retrieval will almost certainl...

   Authors:Farshid Salimijazi, Erika Parra and Buz Barstow

   Citation:Journal of Biological Engineering 2019 13:38

   Published on: 3 May 2019

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5. Content Type:Review

   Tools to reverse-engineer multicellular systems: case studies using the fruit fly

   Reverse-engineering how complex multicellular systems develop and function is a grand challenge for systems bioengineers. This challenge has motivated the creation of a suite of bioengineering tools to develop...

   Authors:Qinfeng Wu, Nilay Kumar, Vijay Velagala and Jeremiah J. Zartman

   Citation:Journal of Biological Engineering 2019 13:33

   Published on: 23 April 2019

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6. Content Type:Review

   Three-dimensional microengineered models of human cardiac diseases

   In vitro three-dimensional (3D) microengineered tissue models have been the recent focus of pathophysiological studies, particularly in the field of cardiovascular research. These models, as classified by 3D b...

   Authors:Jaimeson Veldhuizen, Raymond Q. Migrino and Mehdi Nikkhah

   Citation:Journal of Biological Engineering 2019 13:29

   Published on: 3 April 2019

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7. Content Type:Review

   Microvascular bioengineering: a focus on pericytes

   Capillaries within the microcirculation are essential for oxygen delivery and nutrient/waste exchange, among other critical functions. Microvascular bioengineering approaches have sought to recapitulate many k...

   Authors:Huaning Zhao and John C. Chappell

   Citation:Journal of Biological Engineering 2019 13:26

   Published on: 29 March 2019

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8. Content Type:Review

   Protein-based vehicles for biomimetic RNAi delivery

   Broad translational success of RNA interference (RNAi) technology depends on the development of effective delivery approaches. To that end, researchers have developed a variety of strategies, including chemica...

   Authors:Alex Eli Pottash, Christopher Kuffner, Madeleine Noonan-Shueh and Steven M. Jay

   Citation:Journal of Biological Engineering 2019 13:19

   Published on: 26 February 2019

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9. Content Type:Editorial

   Thematic series on emerging leaders in biological engineering: convergence and new directions

   Over the past two decades, the biological engineering research community has increased its efforts to promote ‘Convergence’. Many research endeavors have thus involved the synergy of multiple perspectives and ...

   Authors:Raj R. Rao

   Citation:Journal of Biological Engineering 2019 13:17

   Published on: 21 February 2019

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10. Content Type:Review

    Current trends in biomarker discovery and analysis tools for traumatic brain injury

    Traumatic brain injury (TBI) affects 1.7 million people in the United States each year, causing lifelong functional deficits in cognition and behavior. The complex pathophysiology of neural injury is a primary...

    Authors:Briana I. Martinez and Sarah E. Stabenfeldt

    Citation:Journal of Biological Engineering 2019 13:16

    Published on: 19 February 2019

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11. Content Type:Review

    Inhibition of bacterial toxin recognition of membrane components as an anti-virulence strategy

    Over recent years, the development of new antibiotics has not kept pace with the rate at which bacteria develop resistance to these drugs. For this reason, many research groups have begun to design and study a...

    Authors:Eric Krueger and Angela C. Brown

    Citation:Journal of Biological Engineering 2019 13:4

    Published on: 19 February 2019

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12. Content Type:Review

    Direct cell reprogramming for tissue engineering and regenerative medicine

    Direct cell reprogramming, also called transdifferentiation, allows for the reprogramming of one somatic cell type directly into another, without the need to transition through an induced pluripotent state. Th...

    Authors:Alexander Grath and Guohao Dai

    Citation:Journal of Biological Engineering 2019 13:14

    Published on: 13 February 2019

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13. Content Type:Review

    Hydrophobins: multifunctional biosurfactants for interface engineering

    Hydrophobins are highly surface-active proteins that have versatile potential as agents for interface engineering. Due to the large and growing number of unique hydrophobin sequences identified, there is growi...

    Authors:Bryan W. Berger and Nathanael D. Sallada

    Citation:Journal of Biological Engineering 2019 13:10

    Published on: 23 January 2019

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14. Content Type:Review

    Nucleic acid delivery to mesenchymal stem cells: a review of nonviral methods and applications

    Mesenchymal stem cells (MSCs) are multipotent stem cells that can be isolated and expanded from many tissues, and are being investigated for use in cell therapies. Though MSC therapies have demonstrated some s...

    Authors:Andrew Hamann, Albert Nguyen and Angela K. Pannier

    Citation:Journal of Biological Engineering 2019 13:7

    Published on: 18 January 2019

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15. Content Type:Review

    Coatings on mammalian cells: interfacing cells with their environment

    The research community is intent on harnessing increasingly complex biological building blocks. At present, cells represent a highly functional component for integration into higher order systems. In this revi...

    Authors:Kara A. Davis, Pei-Jung Wu, Calvin F. Cahall, Cong Li, Anuhya Gottipati and Brad J. Berron

    Citation:Journal of Biological Engineering 2019 13:5

    Published on: 17 January 2019

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16. Content Type:Review

    Bioengineered models to study tumor dormancy

    The onset of cancer metastasis is the defining event in cancer progression when the disease is considered lethal. The ability of metastatic cancer cells to stay dormant for extended time periods and reawaken a...

    Authors:Shreyas S. Rao, Raghu Vamsi Kondapaneni and Akshay A. Narkhede

    Citation:Journal of Biological Engineering 2019 13:3

    Published on: 10 January 2019

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17. Content Type:Review

    Follicle development as an orchestrated signaling network in a 3D organoid

    The ovarian follicle is the structural and functional unit of the ovary, composed of the female gamete (the oocyte) and supportive somatic cells. Follicles are not only the source of a female’s germ cell suppl...

    Authors:Andrea S. K. Jones and Ariella Shikanov

    Citation:Journal of Biological Engineering 2019 13:2

    Published on: 9 January 2019

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18. Content Type:Review

    The effects of low-dose radiation on articular cartilage: a review

    Articular cartilage is a specialized connective tissue, predominately composed of water, collagen, and proteoglycans, that provides a smooth, lubricated surface for articulation in joints. It has long been con...

    Authors:Hannah Cash and Delphine Dean

    Citation:Journal of Biological Engineering 2019 13:1

    Published on: 7 January 2019

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19. Content Type:Review

    Engineered In Vitro Models of Tumor Dormancy and Reactivation

    Metastatic recurrence is a major hurdle to overcome for successful control of cancer-associated death. Residual tumor cells in the primary site, or disseminated tumor cells in secondary sites, can lie in a dor...

    Authors:Shantanu Pradhan, John L. Sperduto, Cindy J. Farino and John H. Slater

    Citation:Journal of Biological Engineering 2018 12:37

    Published on: 27 December 2018

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20. Content Type:Review

    Lymphatic Tissue Engineering and Regeneration

    The lymphatic system is a major circulatory system within the body, responsible for the transport of interstitial fluid, waste products, immune cells, and proteins. Compared to other physiological systems, the...

    Authors:Laura Alderfer, Alicia Wei and Donny Hanjaya-Putra

    Citation:Journal of Biological Engineering 2018 12:32

    Published on: 17 December 2018

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21. Content Type:Research

    An electrically-controlled programmable microfluidic concentration waveform generator

    Biological systems have complicated environmental conditions that vary both spatially and temporally. It becomes necessary to impose time-varying soluble factor concentrations to study such systems, including ...

    Authors:Joshua Garrison, Zidong Li, Barath Palanisamy, Ling Wang and Erkin Seker

    Citation:Journal of Biological Engineering 2018 12:31

    Published on: 14 December 2018

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22. Content Type:Review

    Imaging retinal melanin: a review of current technologies

    The retinal pigment epithelium (RPE) is essential to the health of the retina and the proper functioning of the photoreceptors. The RPE is rich in melanosomes, which contain the pigment melanin. Changes in RPE...

    Authors:Maryse Lapierre-Landry, Joseph Carroll and Melissa C. Skala

    Citation:Journal of Biological Engineering 2018 12:29

    Published on: 4 December 2018

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23. Content Type:Review

    Cell surface engineering and application in cell delivery to heart diseases

    Cell-based therapy has expanded its influence in cancer immunotherapy, regenerative medicine, and tissue engineering. Due to their secretory functions, differentiation capabilities, specific homing effects thr...

    Authors:Daniel Y. Lee, Byung-Hyun Cha, Minjin Jung, Angela S. Kim, David A. Bull and Young-Wook Won

    Citation:Journal of Biological Engineering 2018 12:28

    Published on: 4 December 2018

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24. Content Type:Research

    Bioconversion of cheese whey permeate into fungal oil by Mucor circinelloides

    Oleaginous fungi are efficient tools to convert agricultural waste streams into valuable components. The filamentous fungus Mucor circinelloides was cultivated in whey permeate, a byproduct from cheese production...

    Authors:Lauryn G. Chan, Joshua L. Cohen, Gulustan Ozturk, Marie Hennebelle, Ameer Y. Taha and Juliana Maria L. N. de Moura Bell

    Citation:Journal of Biological Engineering 2018 12:25

    Published on: 14 November 2018

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