J Pediatr Gastroenterol Nutr. 2019 Jan 4. doi: 10.1097/MPG.0000000000002253. [Epub ahead of print]
Change in Prevalence of Family History During Long-term Follow-up of Pediatric-onset Inflammatory Bowel Disease Patients.
Abstract
OBJECTIVES:
To prospectively study changes in prevalence of positive family history (FH+) in pediatric-onset inflammatory bowel disease (IBD) in contrast to previously published cross-sectional data.
METHODS:
An observational cohort study was performed using a prospective pediatric-onset IBD database including 485 patients with disease duration ≥10yrs as of December 2016. Proband characteristics and FH+ were obtained at diagnosis and subsequently from the database, medical records and follow-up telephone interviews in 2006 and 2016.
RESULTS:
Updated 2016 information was obtained from 322 (66%) patients and included in analysis with median follow-up of 18yrs (IQR 14, 26). Prevalence of FH+ increased from 13.7% at diagnosis to 26.6% at 20 years for first-degree relatives and from 38.5% to 52.2% for all relatives. At 20-year follow-up, an additional 10.0% of probands had a sibling, 6.1% had a parent, 1.9% had a grandparent, and 4.5% had a cousin diagnosed with IBD. FH+ at diagnosis was associated with greater risk for additional FH+ at 20 years (43% vs 22%, P < 0.001). Non-Jewish Caucasians had significantly lower risk of any FH+ compared to Jewish Caucasians (P = 0.002), but similar risk to African Americans (P = 0.55). FH+ at diagnosis was not associated with disease type (P = 0.33) or age at diagnosis (P = 0.24).
CONCLUSIONS:
This prospective study documents changes in family history of IBD in pediatric-onset IBD patients over time. Prevalence of FH+ increased for first-degree and all relatives at 20 years by 12.9% and 13.7%, respectively. FH+ at diagnosis was associated with a 2-fold greater likelihood of subsequent FH+ at 20 years.
- PMID:
- 30628987
- DOI:
- 10.1097/MPG.0000000000002253
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