Kidney Int. 2018 Jun;93(6):1270-1272. doi: 10.1016/j.kint.2018.03.005.
"Biomarking" the transition from genetic risk to kidney disease.
Only some individuals carrying the high-risk APOL1 genotype go on to develop kidney disease phenotypes. In this issue of Kidney International, Nadkarni and colleagues report the associations of several biomarkers with renal outcomes in individuals with high-risk APOL1 genotypes. In the era of precision medicine, these findings should translate into improved longitudinal risk assessment for this high-risk population and might also provide additional insights regarding sites and mechanisms of APOL1 nephropathy.