Safety Alerts for Human Medical Products > Lamictal (lamotrigine): Drug Safety Communication - Serious Immune System Reaction

Safety Alerts for Human Medical Products > Lamictal (lamotrigine): Drug Safety Communication - Serious Immune System Reaction

U.S. FDA Advisory

April 25, 2018: Lamictal (lamotrigine): Drug Safety Communication - Serious Immune System Reaction: The FDA is warning that the medicine Lamictal (lamotrigine) for seizures and bipolar disorder can cause a rare but very serious reaction that excessively activates the body's infection-fighting immune system. This can cause severe inflammation throughout the body and lead to hospitalization and death, especially if the reaction is not diagnosed and treated quickly. As a result, the FDA is requiring a new warning about this risk be added to the prescribing information in the lamotrigine drug labels.