Genetic susceptibility in cervical cancer: From bench to bedside.

Bahrami A1,2,3, Hasanzadeh M4, Shahidsales S5, Farazestanian M4, Hassanian SM2,6, Moetamani Ahmadi M1, Maftouh M2, Gharib M7, Yousefi Z4, Kadkhodayan S4, Ferns GA8, Avan A2.

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Abstract

Cervical cancer (CC) is the third most common malignancy in women globally, and persistent infection with the oncogenic human papillomaviruses (HPV) is recognized as the major risk factor. The pathogenesis of CC relies on the interplay between the tumorigenic properties of the HPV and host factors. Host-related genetic factors, including the presence of susceptibility loci for cervix tumor is substantial importance. Preclinical and genome-wide association studies (GWAS) have reported the associations of genetic variations in several susceptibility loci for the development of cervical cancer. However, many of these reports are inconsistent. In this review, we discuss the findings to date of candidate gene association studies, and GWAS in cervical cancer. The associations between these genetic variations with response to chemotherapy are also discussed.