Pertussis: Genomics and Public Health - July 2, 2015

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Pertussis

Pertussis: Genomics and Public Health - July 2, 2015

CDC and Related Info

• Pertussis (Whooping Cough)
• Using AMD technologies to understand changes in virulence of Bordetella pertussis and find effective vaccine components and diagnostic markers
• Genome sequences of 28 Bordetella pertussisU.S. outbreak strains dating from 2010 to 2012.Genome Announcement, December 2013
• Population diversity among Bordetella pertussis isolates, United States, 1935–2009,Emerging Infectious Diseases (2012)

Genomic analysis of isolates from the United Kingdom 2012 pertussis outbreak reveals that Vaccine antigen genes are unusually fast evolving.
Sealey Katie L et al. J. Infect. Dis. 2015 Jul 15. (2) 294-301

Pertussis across the globe: recent epidemiologic trends fom 2000-2013.
Tan T et al. Pediatr. Infect. Dis. J. 2015 Jun 16.

Complete genome sequence of bordetella pertussis D420.
Boinett CJ et al. Genome Announc 2015 (3)

Multiplex real-time PCR assay for detection and differentiation of Bordetella pertussis and Bordetella parapertussis.
Kolodkina V et al. Iran J Microbiol 2014 Jun (3) 140-8

Whole-genome sequence of a bordetella pertussis Brazilian vaccine strain.
Akamatsu MA et al. Genome Announc 2015 (1)

CDC Information: Pertussis, also known as whooping cough, is a highly contagious respiratory disease. It is caused by the bacterium Bordetella pertussis

A total of 9,935 cases of pertussis with onset in 2014 were reported in California, during Jan. 1 through Nov. 26, MMWR, December 5, 2014

CDC information:  Using AMD technologies to understand changes in virulence of Bordetella pertussis and find effective vaccine components and diagnostic markers

CDC paper: Genome sequences of 28 Bordetella pertussis U.S. outbreak strains dating from 2010 to 2012. 
Genome Announcement, December 2013

CDC paper:  Population diversity among Bordetella pertussis isolates, United States, 1935–2009, 
Emerging Infectious Diseases (2012)

Find out which genes have been studied in relation to pertussis occurrence and outcomes from theHuGE Navigator