Ovarian Cancer: Recommendations and Genomic Insights - July 20, 2015

Genomics|Features|Ovarian Cancer

Ovarian Cancer

Ovarian Cancer: Recommendations and Genomic Insights - July 20, 2015

CDC Info

• CDC ovarian cancer information
• CDC fact sheet:Breast and ovarian cancer and family health history
• Hereditary breast and ovarian cancer- Public Health Implementation Toolkit

Does your family history put you at risk of ovarian cancer?Ovarian Cancer Action Tool, UK

Hereditary ovarian cancer: Not only BRCA 1 and 2 genes.
Toss A et al. Biomed Res Int 2015 341723

Genome-wide analysis identifies novel loci associated with ovarian cancer outcomes: findings from the Ovarian Cancer Association Consortium.
Johnatty S et al. Clin. Cancer Res. 2015 Jul 7.

Genome-wide significant risk associations for mucinous ovarian carcinoma
Keleman L et al, Nature Genetics, June 15, 2015

A risk prediction algorithm for ovarian cancer incorporating BRCA1, BRCA2, common alleles and other familial effects.
Jervis S et al. J. Med. Genet. 2015 May 29.

Whole-genome characterization of chemoresistant ovarian cancer
Patch AM et al. Nature, May 28, 2015

Society of Gynecologic Oncology recommendations for the prevention of ovarian cancer.
Walker J L et al. Cancer 2015 Mar 27.

New insights in the pathophysiology of ovarian cancer and implications for screening and prevention.
Nezhat FR et al. Am. J. Obstet. Gynecol. 2015 Mar 25.

Immunotherapeutic approaches to ovarian cancer treatment.
Chester C et al. J Immunother Cancer 2015 7

Two decades beyond BRCA1/2: Homologous recombination, hereditary cancer risk and a target for ovarian cancer therapy.
Walsh CS et al. Gynecol. Oncol. 2015 Feb 25.

Identification of susceptibility genes for peritoneal, ovarian, and deep infiltrating endometriosis using a pooled sample-based genome-wide association study.
Borghese B et al. Biomed Res Int 2015 461024

New insights into tumor immunity revealed by the unique genetic and genomic aspects of ovarian cancer.
Nelson BH et al. Curr. Opin. Immunol. 2015 Feb 21. 93-100

Cancer genomics: why rare is valuable.
Jamshidi F et al. J. Mol. Med. 2015 Apr (4) 369-81

Association between genetic polymorphisms of inflammatory response genes and the risk of ovarian cancer.
Lu Zhi-Hui et al. J. Formos. Med. Assoc. 2015 Feb 3.

Aberrant DNA damage response pathways may predict the outcome of platinum chemotherapy in ovarian cancer.
Stefanou DT et al. PLoS ONE 2015 (2) e0117654

Hereditary predisposition to ovarian cancer, looking beyond BRCA1/BRCA2.
Minion LE et al. Gynecol. Oncol. 2015 Apr (1) 86-92

Epigenetic and genetic dispositions of ovarian carcinomas.
Yamaguchi K et al. Oncoscience 2014 (9) 574-9

Identification of six new susceptibility loci for invasive epithelial ovarian cancer.
Kuchenbaecker KB et al. Nat. Genet. 2015 Feb (2) 164-71

Ovarian Cancer: Recent Genomic Insights - January 20, 2015

Identification of six new susceptibility loci for invasive epithelial ovarian cancer 
Karoline B Kuchenbaecker et al. Nature Genetics, January 12, 2015

Germline mutation in BRCA1 or BRCA2 and ten-year survival for women diagnosed with epithelial ovarian cancer.
Candido Dos Reis FJ, Clin Cancer Res. 2014 Nov 14

Evidence for a time-dependent association between FOLR1 expression and survival from ovarian carcinoma: implications for clinical testing. An ovarian tumour tissue analysis consortium study.
Köbel M, et al. Br J Cancer. 2014 Dec 9;111(12):2297-307

New strategies in ovarian cancer: translating the molecular complexity of ovarian cancer into treatment advances.
Liu J, et al. Clin Cancer Res. 2014 Oct 15;20(20):5150-6

Genomic classification of serous ovarian cancer with adjacent borderline differentiates RAS pathway and TP53-mutant tumors and identifies NRAS as an oncogenic driver.
Emmanuel C, et al. Clin Cancer Res. 2014 Dec 15;20(24):6618-30.

Knowledge-driven genomic interactions: an application in ovarian cancer.
Kim D, Li R, et al. BioData Min. 2014 Sep 9;7:20

Ovarian cancer biomarkers: current state and future implications from high-throughput technologies.
Leung F, et al. Adv Clin Chem. 2014;66:25-77.

Ovarian Cancer Awareness: Genetics & Public Health - September 25, 2014

CDC ovarian cancer information

NCI information: Ovarian cancer: Prevention, genetics, causes

Did you know? >800 genes have been reported in relation to ovarian cancer risk and outcomes, including 21 genomewide association studies. To find out more, visit the HuGE Navigator  

Find out which genetic conditions and tests are associated with ovarian cancer using the NIH Genetic Testing Registry 

CDC fact sheet: Breast and ovarian cancer and family health history

CDC information: Hereditary breast and ovarian cancer- Public Health Implementation Toolkit