Chagas Disease: Genomic Insights into a Neglected Parasitic Infection - July 2, 2015

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Chagas Disease

Chagas Disease: Genomic Insights into a Neglected Parasitic Infection - July 2, 2015

CDC and Related Info

• Parasites - American Trypanosomiasis (also known as Chagas Disease)
• Genetically modifying the insect gut microbiota to control Chagas disease vectors through systemic RNAi.Taracena Mabel L et al.PLoS Negl Trop Dis 2015 Feb (2) e0003358
• Genes reported in relation to chagas, including genomewide association studies via theHuGE Navigator

Machine learning models and pathway genome data base for Trypanosoma cruzi drug discovery.
Ekins S et al. PLoS Negl Trop Dis 2015 Jun (6) e0003878

Retrospective distribution of Trypanosoma cruzi I genotypes in Colombia.
León CM et al. Mem. Inst. Oswaldo Cruz 2015 May (3) 387-93

Deep sequencing of the Trypanosoma cruzi GP63 surface proteases reveals diversity and diversifying selection among chronic and congenital Chagas disease patients.
Llewellyn MS et al. PLoS Negl Trop Dis 2015 Apr (4) e0003458

Gene-deleted live-attenuated Trypanosoma cruzi parasites as vaccines to protect against Chagas disease.
Sánchez-Valdéz FJ et al. Expert Rev Vaccines 2015 May (5) 681-97

Molecular genotyping of Trypanosoma cruzi for lineage assignment and population genetics.
Messenger LA et al. Methods Mol. Biol. 2015 297-337

CDC information: Chagas disease is considered a neglected parasitic infection targeted for public health action

CDC paper: Genetically modifying the insect gut microbiota to control Chagas disease vectors through systemic RNAi.
Taracena Mabel L et al. PLoS Negl Trop Dis 2015 Feb (2) e0003358

Molecular genotyping of Trypanosoma cruzi for lineage assignment and population genetics.
Messenger Louisa A et al. Methods Mol. Biol. 2015 297-337

Host genetics and parasitic infections.
Mangano V D et al. Clin. Microbiol. Infect. 2014 Dec (12) 1265-75

Sequence variation in CYP51A from the Y strain of Trypanosoma cruzi alters its sensitivity to inhibition.
Cherkesova Tatiana S et al. FEBS Lett. 2014 Nov 3. (21) 3878-85

Chagas disease cardiomyopathy: immunopathology and genetics.
Cunha-Neto Edecio et al. Mediators Inflamm. 2014 683230

Genetic variability and geographical diversity of the main Chagas' disease vector Panstrongylus megistus (Hemiptera: Triatominae) in Brazil based on ribosomal DNA intergenic sequences.
Cavassin Francelisse Bridi et al. J. Med. Entomol. 2014 May (3) 616-28

Gene expression changes induced by Trypanosoma cruzi shed microvesicles in mammalian host cells: relevance of tRNA-derived halves.
Garcia-Silva Maria R et al. Biomed Res Int 2014 305239

Find out what genes have been reported in relation to Chagas disease occurrence and outcomes?Search the HuGE Navigator

Prevalence of Chagas disease in Latin-American igmrants living in Europe: A systematic review and meta-analysis.
Requena-Méndez Ana et al. PLoS Negl Trop Dis 2015 Feb (2) e0003540

Trypanosomatids topoisomerase re-visited. New structural findings and role in drug discovery.
Balaña-Fouce Rafael et al. Int J Parasitol Drugs Drug Resist 2014 Dec (3) 326-37

Trypanosoma cruzi, the causal agent of Chagas disease: Boundaries between wild and domestic cycles in Venezuela.
Herrera Leidi et al. Front Public Health 2014 259