Aspirin: Genetic Insights - July 20, 2015

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Aspirin

Aspirin: Genetic Insights - July 20, 2015

Use of Aspirin for prevention of recurrent atherosclerotic cardiovascular disease among adults - 20 states and the District of Columbia, 2013 
CDC MMWR, July 17, 2015

The pharmacogenetic control of antiplatelet response: candidate genes and CYP2C19.
Yang Y et al. Expert Opin Drug Metab Toxicol 2015 Jul 14. 1-19

Use of genetic data to guide therapy in arterial disease.
Ross S et al. J. Thromb. Haemost. 2015 Jun S281-9

Aspirin's active metabolite salicylic acid targets high mobility group box 1 to modulate inflammatory responses.
Choi HW et al. Mol. Med. 2015 Jun 18.

Development of a genetic marker set to diagnose aspirin-exacerbated respiratory disease in a genome-wide association study.
Chang H S et al. Pharmacogenomics J. 2015 Feb 24.

Inflammation and cancer: advances and new agents.
Crusz SM et al. Nat Rev Clin Oncol 2015 Jun 30.

Personalized antiplatelet and anticoagulation therapy: applications and significance of pharmacogenomics.
Beitelshees AL et al. Pharmgenomics Pers Med 2015 43-61

Aspirin: Genetics and Colorectal Cancer Risk - March 24, 2015

Precision medicine: Who benefits from aspirin to prevent colorectal cancer? Francis Collins, NIH Director, Mar 24

Association of aspirin and NSAID use with risk of colorectal cancer according to genetic variants.
Nan H et al. JAMA 2015 Mar 17. (11) 1133-42

Aspirin and NSAID chemoprevention, gene-environment interactions, and risk of colorectal cancer.
Wender RC et al. JAMA 2015 Mar 17. (11) 1111-2

Can aspirin and cancer prevention be ageless companions?
Farag M et al. J Clin Diagn Res 2015 Jan (1) XE01-XE03

P342. Meta-analysis: Does aspirin or non-aspirin non-steroidal anti-inflammatory drug use reduce colorectal cancer risk in patients with inflammatory bowel disease?
J Crohns Colitis 2015 Feb S250

Impact of regular aspirin use on overall and cancer-specific survival in patients with colorectal cancer harboring a PIK3CA mutation.
Kothari N et al. Acta Oncol 2015 Apr (4) 487-92

Chemoprevention of colorectal cancer.
Lang M et al. Dig Dis 2015 (1) 58-67

Molecular pathways: Aspirin and Wnt signaling-A molecularly targeted approach to cancer prevention and treatment.
Gala MK et al. Clin. Cancer Res. 2014 Dec 11.

Gene-environment interaction involving recently identified colorectal cancer susceptibility Loci.
Kantor D et al. Cancer Epidemiol. Biomarkers Prev. 2014 Sep (9) 1824-33

Modulation of age- and cancer-associated DNA methylation change in the healthy colon by aspirin and lifestyle.
Noreen F et al. J. Natl. Cancer Inst. 2014 Jul (7)

Aspirin and the risk of colorectal cancer in relation to the expression of 15-hydroxyprostaglandin dehydrogenase (HPGD).
Fink SP et al. Sci Transl Med 2014 Apr 23. (233) 233re2

Expression of HLA class I antigen, aspirin use, and survival after a diagnosis of colon cancer.
Reimers MS et al. JAMA Intern Med 2014 May (5) 732-9

Genetic variation in UGT genes modify the associations of NSAIDs with risk of colorectal cancer: colon cancer family registry.
Scherer D et al. Genes Chromosomes Cancer 2014 Jul (7) 568-78