Spina Bifida: Public Health and Genomic Insights - May 1, 2015

Genomics|Features|Spina Bifida

Spina Bifida

Spina Bifida: Public Health and Genomic Insights - May 1, 2015

CDC and Related Info

• Data from CDC's spina bifida registry suggests certain patients may have less favorable health outcomes
• Spina bifida is a condition that affects the spine and is usually apparent at birth. It is a type of neural tube defect (NTD)
• Test your knowledge about spina bifida
• Spina bifida basics
• Spina Bifida Registry
• The Spina Bifida Experience series
• Genes reported in relation to spina bifida, including genomewide association studies via theHuGE Navigator

Spina bifida
Nature Reviews Disease Primers, April 30, 2015

Data from CDC's spina bifida registry suggests certain patients may have less favorable health outcomes

The outcome and course of pregnancies complicated with fetal neural tube defects.
Steric M et al. Clin Exp Obstet Gynecol 2015 (1) 57-61

DNA methylation aberrations rather than polymorphisms of FZD3 gene increase the risk of spina bifida in a high-risk region for neural tube defects.
Shangguan S et al. Birth Defects Res. Part A Clin. Mol. Teratol.2015 Jan (1) 37-44

Neural tube defects.
Greene ND et al. Annu. Rev. Neurosci. 2014 221-42

Spina Bifida Awareness Month: Genetics & Public Health - October 16, 2014

CDC information: Spina bifida is a condition that affects the spine and is usually apparent at birth. It is a type of neural tube defect (NTD)

CDC information: Test your knowledge about spina bifida

CDC information: Spina bifida basics

CDC information: Spina Bifida Registry

CDC information: Folic Acid

CDC information: Folic Acid: Birth Defects COUNT, a global initiative to reduce neural tube defects

CDC information: Recurrence prevention for women who have had a pregnancy or child affected by a neural tube defect

CDC paper: Population red blood cell folate concentrations for prevention of neural tube defects: Bayesian model. 
Crider KS, et al.. BMJ. 2014 Jul 29;349:g4554.

Key findings for this paper

CDC videos: The Spina Bifida Experience series

Spina Bifida Association 

National Council on Folic Acid

Mayo Clinic Information:  Couples who've had one child with a neural tube defect have a slightly higher chance of having another baby with the same defect. That risk increases if two previous children have been affected by the condition

Check out genetic conditions and tests related to spina bifida and other neural tube defects from theNIH Genetic Testing Registry

Check out which genes have been associated with risk of spina bifida and other neural tube defects from the HuGE Navigator