Genetic Analysis Workshop 18: Methods and strategies for analyzing human sequence and phenotype data in members of extended pedigrees.

Bickeböller H1, Bailey JN2, Beyene J3, Cantor RM4, Cordell HJ5, Culverhouse RC6, Engelman CD7, Fardo DW8, Ghosh S9, König IR10, Lorenzo Bermejo J11,Melton PE12, Santorico SA13, Satten GA14, Sun L15, Tintle NL16, Ziegler A17, MacCluer JW18, Almasy L18.

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Abstract

Genetic Analysis Workshop 18 provided a platform for developing and evaluating statistical methods to analyze whole-genome sequence data from a pedigree-based sample. In this article we present an overview of the data sets and the contributions that analyzed these data. The family data, donated by the Type 2 Diabetes Genetic Exploration by Next-Generation Sequencing in Ethnic Samples Consortium, included sequence-level genotypes based on sequencing and imputation, genome-wide association genotypes from prior genotyping arrays, and phenotypes from longitudinal assessments. The contributions from individual research groups were extensively discussed before, during, and after the workshop in theme-based discussion groups before being submitted for publication.