An MHC class I immune evasion gene of Marek׳s disease virus. - PubMed - NCBI
Virology. 2014 Nov 26;475C:88-95. doi: 10.1016/j.virol.2014.11.008. [Epub ahead of print]
An MHC class I immune evasion gene of Marek׳s disease virus.
Abstract
Marek׳s disease virus (MDV) is a widespread α-herpesvirus of chickens that causes T cell tumors. Acute, but not latent, MDV infection has previously been shown to lead to downregulation of cell-surface MHC class I (Virology 282:198-205 (2001)), but the gene(s) involved have not been identified. Here we demonstrate that an MDV gene, MDV012, is capable of reducing surface expression of MHC class I on chicken cells. Co-expression of an MHC class I-binding peptide targeted to the endoplasmic reticulum (bypassing the requirement for the TAP peptide transporter) partially rescued MHC class I expression in the presence of MDV012, suggesting that MDV012 is a TAP-blocking MHC class I immune evasion protein. This is the first unique non-mammalian MHC class I immune evasion gene identified, and suggests that α-herpesviruses have conserved this function for at least 100 million years. Copyright © 2014 Elsevier Inc. All rights reserved.
KEYWORDS:
Immune evasion; Major histocompatibility complex class I; Marek׳s disease virus
- PMID:
- 25462349
- [PubMed - as supplied by publisher]
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