Current Highlight from May 30, 2014
Recovery of Burkholderia Strains from Pharmaceutical Water Scientists from NCTR, Center for Drug Evaluation and Research, Rutgers, Albany State University, and the University of Michigan have shown that standard direct culture methods may not reliably recover Burkholderia cenocepacia present in pharmaceutical water. However, the use of Tryptic Soy Broth (TSB) or Reasoner’s 2nd Broth (R2AB) enrichment improves recovery of these microorganisms. Various solid and liquid nonselective media were evaluated for recovery of Burkholderia strains which remain viable in distilled water for prolonged periods (40 days). Burkholderia contamination was responsible for recalls of both sterile and non-sterile pharmaceutical products, with contaminated water systems being the most common source in pharmaceutical settings. These results may assist in improving detection assays with recovery and enrichment strategies to maximize recovery of these microorganisms. The study is available online at Journal of Industrial Microbiology & Biotechnology
(http://dx.doi.org/10.1007/s10295-014-1442-3).For additional information, please contact Carl E. Cerniglia, Ph.D., Director, Division of Microbiology, FDA/NCTR.
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