jueves, 26 de septiembre de 2013

Omega-3 fatty acids and domain-specific cognitive aging

Omega-3 fatty acids and domain-specific cognitive aging

  • Article

Omega-3 fatty acids and domain-specific cognitive aging

Secondary analyses of data from WHISCA

  1. Jennifer G. Robinson, MD, MPH
  1. Correspondence to Eric Ammann: eric-ammann@uiowa.edu
  1. Neurology 10.1212/WNL.0b013e3182a9584c
  1. Also available:
  2. Data Supplement


Objective: To test the hypothesis that higher levels of red blood cell (RBC) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) have a protective association with domain-specific cognitive function in women aged 65 years and older.
Methods: A total of 2,157 women with normal cognition enrolled in a clinical trial of postmenopausal hormone therapy were followed with annual cognitive testing for a median of 5.9 years. In this retrospective cohort study, we assessed the relationship between prerandomization RBC DHA + EPA levels and a) cognitive measures at baseline, and b) cognitive change over time. Endpoints were composite cognitive function and performance in 7 cognitive domains: fine motor speed, verbal memory, visual memory, spatial ability, verbal knowledge, verbal fluency, and working memory.
Results: After adjustment for demographic, clinical, and behavioral characteristics, no significant (p < 0.01) cross-sectional cognitive differences were found between women in the high and low DHA + EPA tertiles at the time of the first annual cognitive battery. In addition, no significant (p < 0.01) differences were found between the high and low DHA + EPA tertiles in the rate of cognitive change over time.
Conclusions: We did not find an association between RBC DHA + EPA levels and age-associated cognitive decline in a cohort of older, dementia-free women.
  • Received March 18, 2013.
  • Accepted in final form July 23, 2013.

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