lunes, 30 de septiembre de 2013

Supplemental screening ultrasound increa... [Arch Gynecol Obstet. 2013] - PubMed - NCBI

Supplemental screening ultrasound increa... [Arch Gynecol Obstet. 2013] - PubMed - NCBI

2013 Sep 18. [Epub ahead of print]

Supplemental screening ultrasound increases cancer detection yield in BRCA1 and BRCA2 mutation carriers.

Source

Center for Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany, kristin.bosse@med.uni-tuebingen.de.

Abstract

INTRODUCTION:

This study aimed at evaluating the efficacy of ultrasound for the early detection of breast cancers in BRCA1/2 mutation carriers.

METHODS:

Between 01/1997 and 10/2008 221 BRCA1/2 mutation carriers participated in a breast cancer screening program which included semi-annual ultrasound in combination with annual mammography and magnetic resonance imaging (MRI). Women underwent on average (median) five semi-annual screening rounds with a range of one to 22 appointments, totaling 1,855 rounds of screening. All three imaging modalities were coded according to the American College of Radiology (BI-RADS classification).

RESULTS:

In total, we detected 27 BRCA-associated breast cancers in 25 patients. The sensitivity was 77 % for ultrasound, 27 % for mammography, and 100 % for MRI. Three tumors were detected directly as a result of only the semi-annual ultrasound screen.

CONCLUSIONS:

Due to the specific tumor morphology and the considerably elevated tumor doubling time, mutation carriers benefit from the addition of semi-annual ultrasound screening as a sensitive and cost-effective method.

PMID:
24045978
[PubMed - as supplied by publisher]

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