Arch Gynecol Obstet. 2013 Sep 18. [Epub ahead of print]
Supplemental screening ultrasound increases cancer detection yield in BRCA1 and BRCA2 mutation carriers.
SourceCenter for Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany, email@example.com.
INTRODUCTION:This study aimed at evaluating the efficacy of ultrasound for the early detection of breast cancers in BRCA1/2 mutation carriers.
METHODS:Between 01/1997 and 10/2008 221 BRCA1/2 mutation carriers participated in a breast cancer screening program which included semi-annual ultrasound in combination with annual mammography and magnetic resonance imaging (MRI). Women underwent on average (median) five semi-annual screening rounds with a range of one to 22 appointments, totaling 1,855 rounds of screening. All three imaging modalities were coded according to the American College of Radiology (BI-RADS classification).
RESULTS:In total, we detected 27 BRCA-associated breast cancers in 25 patients. The sensitivity was 77 % for ultrasound, 27 % for mammography, and 100 % for MRI. Three tumors were detected directly as a result of only the semi-annual ultrasound screen.
CONCLUSIONS:Due to the specific tumor morphology and the considerably elevated tumor doubling time, mutation carriers benefit from the addition of semi-annual ultrasound screening as a sensitive and cost-effective method.
- [PubMed - as supplied by publisher]