lunes, 17 de junio de 2013

Evidence-based recommendations for the... [Semin Arthritis Rheum. 2013] - PubMed - NCBI

Evidence-based recommendations for the... [Semin Arthritis Rheum. 2013] - PubMed - NCBI


Semin Arthritis Rheum. 2013 Jun 3. pii: S0049-0172(13)00067-X. doi: 10.1016/j.semarthrit.2013.04.011. [Epub ahead of print]


Evidence-based recommendations for the practical management of Familial Mediterranean Fever.





Source


Centre national de Référence des maladies Auto-Inflammatoires, CeRéMAI, Centre Hospitalier de Versailles, 177, rue de Versailles, 78150 Le Chesnay Cedex, France. Electronic address: Vhentgen@ch-versailles.fr



Abstract




AIM:


Familial Mediterranean Fever (FMF) is the most common recurrent autoinflammatory fever syndrome. Still, many issues-e.g.: colchicine dosage adjustment, maximum dosage of colchicine in children and adults, definition of colchicine resistance, alternative treatment solutions in colchicine-resistant patients, and genetic screening for asymptomatic siblings-have not yet been standardized. The current paper aims at summarizing consensus recommendations to approach these issues.


METHODS:


A literature review concerning these practical management questions was performed through PubMed. On the basis of this analysis, expert recommendations were developed during a consensus meeting of caregivers from France and Israel.


RESULTS:


A patient experiencing more than four FMF attacks a year needs colchicine dose adjustment. In case of persistent attacks (≥6 per year) in patients with maximum doses of colchicine (2mg in children; 3mg in adults), alternative treatment to colchicine with IL1 inhibitors should be considered. Routine genetic testing for MEFV mutations in asymptomatic siblings of an index case is not recommended.


CONCLUSION:


This is a first attempt to resolve practical questions in the daily management of FMF patients.
Copyright © 2013 Elsevier Inc. All rights reserved.



PMID:

23742958
[PubMed - as supplied by publisher]

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