lunes, 17 de junio de 2013

Evidence-based recommendations for the... [Semin Arthritis Rheum. 2013] - PubMed - NCBI

Evidence-based recommendations for the... [Semin Arthritis Rheum. 2013] - PubMed - NCBI

Semin Arthritis Rheum. 2013 Jun 3. pii: S0049-0172(13)00067-X. doi: 10.1016/j.semarthrit.2013.04.011. [Epub ahead of print]

Evidence-based recommendations for the practical management of Familial Mediterranean Fever.


Centre national de Référence des maladies Auto-Inflammatoires, CeRéMAI, Centre Hospitalier de Versailles, 177, rue de Versailles, 78150 Le Chesnay Cedex, France. Electronic address:



Familial Mediterranean Fever (FMF) is the most common recurrent autoinflammatory fever syndrome. Still, many issues-e.g.: colchicine dosage adjustment, maximum dosage of colchicine in children and adults, definition of colchicine resistance, alternative treatment solutions in colchicine-resistant patients, and genetic screening for asymptomatic siblings-have not yet been standardized. The current paper aims at summarizing consensus recommendations to approach these issues.


A literature review concerning these practical management questions was performed through PubMed. On the basis of this analysis, expert recommendations were developed during a consensus meeting of caregivers from France and Israel.


A patient experiencing more than four FMF attacks a year needs colchicine dose adjustment. In case of persistent attacks (≥6 per year) in patients with maximum doses of colchicine (2mg in children; 3mg in adults), alternative treatment to colchicine with IL1 inhibitors should be considered. Routine genetic testing for MEFV mutations in asymptomatic siblings of an index case is not recommended.


This is a first attempt to resolve practical questions in the daily management of FMF patients.
Copyright © 2013 Elsevier Inc. All rights reserved.


[PubMed - as supplied by publisher]

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