Int J Epidemiol. 2012 Jun;41(3):686-704. doi: 10.1093/ije/dys010. Epub 2012 May 16.
Recommendations and proposed guidelines for assessing the cumulative evidence on joint effects of genes and environments on cancer occurrence in humans.
Boffetta P, Winn DM, Ioannidis JP, Thomas DC, Little J, Smith GD, Cogliano VJ, Hecht SS, Seminara D, Vineis P, Khoury MJ.
Source
Tisch Cancer Institute, Mount Sinai School of Medicine, NY, USA. paolo.boffetta@mssm.eduAbstract
We propose guidelines to evaluate the cumulative evidence of gene-environment (G × E) interactions in the causation of human cancer. Our approach has its roots in the HuGENet and IARC Monographs evaluation processes for genetic and environmental risk factors, respectively, and can be applied to common chronic diseases other than cancer. We first review issues of definitions of G × E interactions, discovery and modelling methods for G × E interactions, and issues in systematic reviews of evidence for G × E interactions, since these form the foundation for appraising the credibility of evidence in this contentious field. We then propose guidelines that include four steps: (i) score the strength of the evidence for main effects of the (a) environmental exposure and (b) genetic variant; (ii) establish a prior score category and decide on the pattern of interaction to be expected; (iii) score the strength of the evidence for interaction between the environmental exposure and the genetic variant; and (iv) examine the overall plausibility of interaction by combining the prior score and the strength of the evidence and interpret results. We finally apply the scheme to the interaction between NAT2 polymorphism and tobacco smoking in determining bladder cancer risk.
Comment in
- The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlCommentary: reporting and assessing evidence for interaction: why, when and how? [Int J Epidemiol. 2012]
- The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlCommentary: thoughts on assessing evidence for gene by environment interaction. [Int J Epidemiol. 2012]
- PMID:
- 22596931
- [PubMed - indexed for MEDLINE]
- PMCID:
- PMC3481885
- [Available on 2013/6/1]
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