Also in the Journals: Study Compares Screening Methods for Lynch Syndrome
A large, population-based, international study found that routine screening of colorectal tumors for DNA mismatch repair (MMR) genes was more sensitive than several other screening methods for identifying patients with Lynch syndrome. The researchers compared tumor MMR testing with three other screening strategies: the Bethesda guidelines
, the Jerusalem recommendations, and another strategy based on an analysis of variables associated with Lynch syndrome. Their findings were published in JAMA today.
Although MMR testing offered only a “modest” diagnostic improvement, up to 15 percent of people with Lynch syndrome could remain undiagnosed without routine screening of colorectal tumors. And, identifying those with Lynch syndrome is critical to diagnosing relatives before they develop symptoms, so they can take preventive measures to decrease their risk of disease and death, explained the authors.
This research was supported by grants from the National Institutes of Health (CA67941 and CA16058).
Further reading: “Routine Lynch Syndrome Screening Varies at U.S. Cancer Centers”
A large, population-based, international study found that routine screening of colorectal tumors for DNA mismatch repair (MMR) genes was more sensitive than several other screening methods for identifying patients with Lynch syndrome. The researchers compared tumor MMR testing with three other screening strategies: the Bethesda guidelines
, the Jerusalem recommendations, and another strategy based on an analysis of variables associated with Lynch syndrome. Their findings were published in JAMA today.Although MMR testing offered only a “modest” diagnostic improvement, up to 15 percent of people with Lynch syndrome could remain undiagnosed without routine screening of colorectal tumors. And, identifying those with Lynch syndrome is critical to diagnosing relatives before they develop symptoms, so they can take preventive measures to decrease their risk of disease and death, explained the authors.
This research was supported by grants from the National Institutes of Health (CA67941 and CA16058).
Further reading: “Routine Lynch Syndrome Screening Varies at U.S. Cancer Centers”
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