lunes, 29 de octubre de 2012

JAMA Network | JAMA: The Journal of the American Medical Association | Lynch Syndrome in Patients With Colorectal CancerFinding the Needle in the Haystack

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JAMA Network | JAMA: The Journal of the American Medical Association | Lynch Syndrome in Patients With Colorectal CancerFinding the Needle in the Haystack


Editorial |


Lynch Syndrome in Patients With Colorectal CancerFinding the Needle in the Haystack



Uri Ladabaum, MD, MS; James M. Ford, MD



JAMA. 2012;308(15):1581-1583. doi:10.1001/jama.2012.14171.









Identification of individuals at increased risk of hereditary cancer allows for the possibility of screening and early cancer detection, possibly resulting in decreased disease-specific mortality, and is the justification for germline genetic testing for specific cancer risk alleles. However, factors of prevalence and age-specific penetrance, effectiveness and invasiveness of screening procedures, and efficacy of early detection influence the potential benefit of such an approach.

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