Challenges and Controversies in Defining Totally Drug-Resistant Tuberculosis - - Emerging Infectious Disease journal - CDC
Challenges and Controversies in Defining Totally Drug-Resistant Tuberculosis
Suggested citation for this article
A 2011 report from India described 4 patients with tuberculosis (TB) for whom drug susceptibility testing (DST) of Mycobacterium tuberculosis cultures showed phenotypic resistance to all of 12 drugs examined (1). The authors of that report proposed the term: totally drug-resistant TB, abbreviated as TDR TB. To our knowledge, this was the fourth reported series of TB cases that showed resistance to all drugs tested, heralding the advent of TB strains resistant to all available anti-TB drugs (1–5).