Copyright © 2012 The American Society of Human Genetics All rights reserved.
The American Journal of Human Genetics, 14 June 2012
The American Journal of Human Genetics, 14 June 2012
doi:10.1016/j.ajhg.2012.05.009
Report
Genetic Associations for Activated Partial Thromboplastin Time and Prothrombin Time, their Gene Expression Profiles, and Risk of Coronary Artery Disease
Weihong Tang1, 30, , , Christine Schwienbacher2, 3, 30, Lorna M. Lopez4, 5, 30, Yoav Ben-Shlomo6, Tiphaine Oudot-Mellakh7, Andrew D. Johnson8, 9, 10, Nilesh J. Samani11, 12, 31, Saonli Basu13, Martin Gögele2, Gail Davies5, Gordon D.O. Lowe14, David-Alexandre Tregouet7, Adrian Tan13, James S. Pankow1, Albert Tenesa15, 16, Daniel Levy9, Claudia B. Volpato2, Ann Rumley14, Alan J. Gow4, 5, Cosetta Minelli2, John W.G. Yarnell17, David J. Porteous4, 18, John M. Starr4, 19, John Gallacher20, Eric Boerwinkle21, Peter M. Visscher22, Peter P. Pramstaller2, 23, 24, Mary Cushman25, Valur Emilsson26, Andrew S. Plump27, Nena Matijevic28, Pierre-Emmanuel Morange29, Ian J. Deary4, 5, 30, Andrew A. Hicks2, 30 and Aaron R. Folsom1, 301 Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454, USA
2 Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC); affiliated institute of the University of Lübeck, Lübeck, Germany), Viale Druso 1, 39100 Bolzano, Italy
3 Department of Experimental and Diagnostic Medicine, University of Ferrara, 44121 Ferrara, Italy
4 Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
5 Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
6 School of Social and Community Medicine, University of Bristol, Bristol BS8 2PS, UK
7 INSERM UMR_S 937; Institute of Cardiometabolism and Nutrition (ICAN); Université Pierre et Marie Curie (UPMC, Paris 6); 75013 Paris, France
8 National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA
9 Center for Population Studies, National Heart, Lung and Blood Institute, Bethesda, MD 20824, USA
10 Division of Intramural Research, National Heart, Lung and Blood Institute, Bethesda, MD 20824, USA
11 Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Leicester LE3 9QP, UK
12 National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK
13 Division of Biostatistics, University of Minnesota, Minneapolis, MN 55455, USA
14 Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK
15 Institute of Genetics and Molecular Medicine, Medical Research Council (MRC) Human Genetics Unit, Edinburgh EH4 2XU, UK
16 The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian EH25 9RG, UK
17 Epidemiology Research Group, Queen's University Belfast, Grosvenor Road, Belfast BT12 6BJ, UK
18 Medical Genetics Section, University of Edinburgh, Edinburgh EH4 2XU, UK
19 Alzheimer Scotland Dementia Research Centre, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
20 Department of Primary Care and Public Health, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK
21 Human Genetics Center and Human Genome Sequencing Center, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
22 Queensland Statistical Genetics, Queensland Institute of Medical Research, Brisbane 4029, Australia
23 Department of Neurology, General Central Hospital, 39100 Bolzano, Italy
24 Department of Neurology, University of Lübeck, 23538 Lübeck, Germany
25 Departments of Medicine and Pathology, University of Vermont, Burlington, VT 05405, USA
26 Molecular Programming and Research Informatics, Merck & Co., Inc., Rahway, NJ 07065, USA
27 Department of Cardiovascular Disease, Merck Research Laboratory, Rahway, NJ 07065, USA
28 Hemostasis Laboratory, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
29 INSERM, UMR_S 1062, Aix-Marseille Université, 13385 Marseille, France
Corresponding author2 Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC); affiliated institute of the University of Lübeck, Lübeck, Germany), Viale Druso 1, 39100 Bolzano, Italy
3 Department of Experimental and Diagnostic Medicine, University of Ferrara, 44121 Ferrara, Italy
4 Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
5 Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
6 School of Social and Community Medicine, University of Bristol, Bristol BS8 2PS, UK
7 INSERM UMR_S 937; Institute of Cardiometabolism and Nutrition (ICAN); Université Pierre et Marie Curie (UPMC, Paris 6); 75013 Paris, France
8 National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA
9 Center for Population Studies, National Heart, Lung and Blood Institute, Bethesda, MD 20824, USA
10 Division of Intramural Research, National Heart, Lung and Blood Institute, Bethesda, MD 20824, USA
11 Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Leicester LE3 9QP, UK
12 National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK
13 Division of Biostatistics, University of Minnesota, Minneapolis, MN 55455, USA
14 Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK
15 Institute of Genetics and Molecular Medicine, Medical Research Council (MRC) Human Genetics Unit, Edinburgh EH4 2XU, UK
16 The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian EH25 9RG, UK
17 Epidemiology Research Group, Queen's University Belfast, Grosvenor Road, Belfast BT12 6BJ, UK
18 Medical Genetics Section, University of Edinburgh, Edinburgh EH4 2XU, UK
19 Alzheimer Scotland Dementia Research Centre, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
20 Department of Primary Care and Public Health, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK
21 Human Genetics Center and Human Genome Sequencing Center, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
22 Queensland Statistical Genetics, Queensland Institute of Medical Research, Brisbane 4029, Australia
23 Department of Neurology, General Central Hospital, 39100 Bolzano, Italy
24 Department of Neurology, University of Lübeck, 23538 Lübeck, Germany
25 Departments of Medicine and Pathology, University of Vermont, Burlington, VT 05405, USA
26 Molecular Programming and Research Informatics, Merck & Co., Inc., Rahway, NJ 07065, USA
27 Department of Cardiovascular Disease, Merck Research Laboratory, Rahway, NJ 07065, USA
28 Hemostasis Laboratory, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
29 INSERM, UMR_S 1062, Aix-Marseille Université, 13385 Marseille, France
30 These authors contributed equally to this work
31 On behalf of the CARDIoGRAM Consortium; a full list of CARDIoGRAM members can be found in the Supplemental Data
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