lunes, 12 de marzo de 2012

Genetic Influences on Developmental Smoking Trajec... [Addiction. 2012] - PubMed - NCBI

Genetic Influences on Developmental Smoking Trajec... [Addiction. 2012] - PubMed - NCBI

Addiction. 2012 Mar 2. doi: 10.1111/j.1360-0443.2012.03871.x. [Epub ahead of print]

Genetic Influences on Developmental Smoking Trajectories.


Department of Psychiatry, Washington University School of Medicine, St. Louis, MO.


Aims:   To investigate the relative contribution of genetic and environmental factors on smoking trajectory membership and to test whether individual smoking trajectories represent phenotypic thresholds of increasing genetic risk along a common genetic liability dimension. Design:  Prospective study of a birth cohort of female like-sex twin pairs. Setting:   Participants completed diagnostic interview surveys 4 times from adolescence (average age 16) through young adulthood (average age 25). Participants:  Female twins who had smoked ≥100 cigarettes lifetime (n = 1466 regular smokers). Measurements:  Number of cigarettes smoked per day during the heaviest period of smoking (2 waves) or during the past 12 months (2 waves). Findings:  A 4-trajectory class solution provided the best fit to cigarette consumption data and was characterized by Low (n=564, 38.47%), Moderate (n=366, 24.97%), and High level smokers (n=197, 13.44%), and smokers who increased their smoking from adolescence to young adulthood (n=339, 23.12%). The best genetic model fit was a 3-category model that comprised the Low, a combined Increasing + Moderate, and High trajectories. This trajectory categorization was heritable (72.7%) with no evidence for significant contribution from shared environmental factors. Conclusions:  The way that smoking patterns develop in adolescence has a high level of heritability.
© 2012 The Authors, Addiction © 2012 Society for the Study of Addiction.
[PubMed - as supplied by publisher]

No hay comentarios:

Publicar un comentario