Addiction. 2012 Mar 2. doi: 10.1111/j.1360-0443.2012.03871.x. [Epub ahead of print]
Genetic Influences on Developmental Smoking Trajectories.
SourceDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO.
AbstractAims: To investigate the relative contribution of genetic and environmental factors on smoking trajectory membership and to test whether individual smoking trajectories represent phenotypic thresholds of increasing genetic risk along a common genetic liability dimension. Design: Prospective study of a birth cohort of female like-sex twin pairs. Setting: Participants completed diagnostic interview surveys 4 times from adolescence (average age 16) through young adulthood (average age 25). Participants: Female twins who had smoked ≥100 cigarettes lifetime (n = 1466 regular smokers). Measurements: Number of cigarettes smoked per day during the heaviest period of smoking (2 waves) or during the past 12 months (2 waves). Findings: A 4-trajectory class solution provided the best fit to cigarette consumption data and was characterized by Low (n=564, 38.47%), Moderate (n=366, 24.97%), and High level smokers (n=197, 13.44%), and smokers who increased their smoking from adolescence to young adulthood (n=339, 23.12%). The best genetic model fit was a 3-category model that comprised the Low, a combined Increasing + Moderate, and High trajectories. This trajectory categorization was heritable (72.7%) with no evidence for significant contribution from shared environmental factors. Conclusions: The way that smoking patterns develop in adolescence has a high level of heritability.
© 2012 The Authors, Addiction © 2012 Society for the Study of Addiction.
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