viernes, 16 de marzo de 2012

Exposure to diesel exhaust linked to lung cancer in miners - National Cancer Institute

Exposure to diesel exhaust linked to lung cancer in miners - National Cancer Institute


Heavy exposure to diesel exhaust linked to lung cancer death in miners

In a study of non-metal miners in the United States, federal government scientists reported that heavy exposure to diesel exhaust increased risk of death from lung cancer. The study was carried out by researchers from the National Cancer Institute (NCI), part of the National Institutes of Health, and the National Institute for Occupational Safety and Health (NIOSH), part of the Centers for Disease Control and Prevention, both parts of HHS. The results were distributed in two papers on March 2, 2012, from the Journal of the National Cancer Institute and they will be posted to the JNCI website on March 5, 2012.
The research, all part of the Diesel Exhaust in Miners Study, was designed to evaluate cancer risk from diesel exhaust, particularly as it may relate to lung cancer, among 12,315 workers at eight non-metal mining facilities. The facilities were located in Missouri (1 limestone mine), New Mexico (3 potash mines), Ohio (1 salt mine), and Wyoming (3 trona mines, which process an ore used in soda ash).
The investigators selected underground mines for their study setting because the heavy equipment used in these mines frequently runs on diesel fuel. In the fairly enclosed environments of these mines, exhaust builds up in the air to levels considerably higher than those found in other occupational settings—like trucking depots or shipyards—and many times higher than the air inhaled by the general population. The investigators selected only non-metal mines because of their characteristically low levels of other exposures that may be related to lung cancer risk, such as radon, silica, and asbestos.
Large yellow diesel-powered equipment sitting in underground mineHealth outcomes associated with exposure to diesel exhaust were reported in two complementary papers. The first documented the risk of dying from any cause, with an emphasis on lung cancer, using data from the full study population (the cohort study). The second (the case-control study) reported on the lung cancer deaths in the cohort study. In the case-control study, investigators obtained detailed information on lung cancer risk factors, including smoking, employment in other high-risk jobs, and history of other respiratory diseases. Both papers reported an exposure-response relationship with higher risks at increased exposure levels.
“It was vitally important to undertake a large study of diesel exhaust and lung cancer based on a quantitative assessment of historical exposure, taking into account smoking and other potentially relevant factors in order to estimate lung cancer risk,” said lead author of the case-control study, Debra T. Silverman, Sc.D., chief of the Occupational and Environmental Epidemiology Branch in the Division of Cancer Epidemiology and Genetics (DCEG) at NCI.
To quantify exposure for each worker, the investigators collected thousands of measurements of constituents of diesel exhaust in the air at each mine and combined those data with historical exposure information. Importantly, diesel exhaust levels were quantified by measurements and estimates of one of its key components, respirable elemental carbon, which is considered the best index of diesel exhaust in underground mining. The same exposure measurements were used in both the cohort and case-control analyses. The methods for this effort were published previously in four papers in the Annals of Occupational Hygiene in 2010. A fifth paper—an evaluation of the exposure assessment—was published March 2012 in the same journal.
Michael D. Attfield, Ph.D., who led the cohort study while at NIOSH, found that the risk of lung cancer among heavily exposed underground workers was five times the risk observed among workers in the lowest exposure category.
Turning to the case-control study, it confirmed the lung cancer findings from the cohort study. When the investigators took into account smoking and other lung cancer risk factors, the data showed a three-fold risk of lung cancer death overall and about a five-fold risk for heavily exposed underground workers, which is consistent with the cohort analysis.
For never smokers, risk of lung cancer death increased with increasing diesel exhaust exposure. “These data are especially revealing as they show the effect of diesel exhaust in the absence of smoking,” said Silverman. Although based on small numbers, non-smokers with the highest level of diesel exposure were seven times more likely to die from lung cancer than non-smokers in the lowest exposure category.
“This landmark study has informed on the lung cancer risks for underground mine workers, but the findings suggest that the risks may extend to other workers exposed to diesel exhaust in the United States and abroad, and to people living in urban areas where diesel exhaust levels are elevated,” said Joseph F. Fraumeni, Jr., M.D., director, DCEG.
For more information on the Diesel Exhaust in Miners Study, please see Questions & Answers at http://www.cancer.gov/newscenter/pressreleases/2012/DieselMinersQandA.

References:
Silverman DT, Samanic CM, Lubin JH, et al. The diesel exhaust in miners study: a nested case-control study of lung cancer and diesel exhaust. J Natl Cancer Inst. March 2, 2012. doi:10.1093/jnci/djs034.
Attfield MD, Schlieff PL, Lubin JH, et al. The diesel exhaust in miners study: a cohort mortality study with emphasis on lung cancer. J Natl Cancer Inst. March 2, 2012. doi:10.1093/jnci/djs035.

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For more information about NCI’s Division of Cancer Epidemiology and Genetics, please visit: http://dceg.cancer.gov
NCI leads the National Cancer Program and the NIH effort to dramatically reduce the burden of cancer and improve the lives of cancer patients and their families, through research into prevention and cancer biology, the development of new interventions, and the training and mentoring of new researchers. For more information about cancer, please visit the NCI Web site at www.cancer.gov or call NCI's Cancer Information Service at 1-800-4-CANCER (1-800-422-6237).
The National Institutes of Health (NIH) — NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.
NIOSH is the federal agency that conducts research and makes recommendations for preventing work-related injuries and illnesses. It was established under the Occupational Safety and Health Act of 1970. For further information, visit http://www.cdc.gov/niosh.

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