Familial gastric cancer: update for practice manag... [Fam Cancer. 2010] - PubMed result

Fam Cancer. 2010 Dec 24. [Epub ahead of print]
Familial gastric cancer: update for practice management.

Corso G, Marrelli D, Roviello F.

Department of Human Pathology and Oncology, Section of General Surgery and Surgical Oncology, Translational Research Laboratory, University of Siena, Siena, Italy, corso.giov@tiscali.it.

Abstract

About 90% of gastric carcinoma presents a sporadic setting and only 10% shows a familial cluster; among this group, 1-3% are considered as hereditary syndromes, with a clear genetic pathway. The most important genetic mechanisms are associated with CDH1 germline mutations, causing the hereditary diffuse gastric cancer syndrome. Other inherited predispositions with gastric carcinoma are the hereditary nonpolyposis colorectal cancer, Li-Fraumeni and Peutz-Jeghers syndromes. In this brief update, we described these principal hereditary syndromes offering a simple management to physicians where are these diseases diagnosed.

PMID: 21184285 [PubMed - as supplied by publisher]

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Familial gastric cancer: update for practice manag... [Fam Cancer. 2010] - PubMed result