Current status on Alzheimer disease molecular gene... [Hum Mol Genet. 2010] - PubMed result

Genomics in the Scientific Literature
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Hum Mol Genet. 2010 Apr 19. [Epub ahead of print]

Current status on Alzheimer disease molecular genetics: from past, to present, to future.
Bettens K, Sleegers K, Van Broeckhoven C.

Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerpen, Belgium.

Abstract
Linkage studies, candidate gene and whole genome association studies have resulted in a tremendous amount of putative risk genes for Alzheimer disease (AD). Yet, besides the three causal genes - amyloid precursor protein and presenilin 1 and 2 genes - and one risk gene apolipoprotein E (APOE), no single functional risk variant was identified. Discussing the possible involvement of rare alleles and other types of genetic variants, this review summarizes the current knowledge on the genetic spectrum of AD and integrates different approaches and recent discoveries by genome wide association studies.

PMID: 20388643 [PubMed - as supplied by publisher]Free Article

Current status on Alzheimer disease molecular gene... [Hum Mol Genet. 2010] - PubMed result