miércoles, 24 de junio de 2009



The Center for Toxicoinformatics conducts research in bioinformatics and chemoinformatics, and develops and coordinates informatics capabilities within NCTR, across FDA Centers, and in the larger toxicology community. The goal of the toxicoinformatics group is to develop methods for the analysis and integration of omics (genomic, transcriptomic, proteomic, and metabolomic) databases with the objective of knowledge discovery and the elucidation of mechanisms of toxicity.

Some of NCTR's toxicoinformatics projects and tools include:

- DNA microarray data management, mining, analysis, and interpretation software

Decision Forest
- A novel pattern recognition method for analysis of data from microarray experiments, proteomics research, and predictive toxicology

Endocrine Disruptor Knowledge Base (EDKB)
-Scientific resources to predict estrogen and androgen activity

MicroArray Quality Control (MAQC) Project
-Development of microarray quality control metrics and thresholds

- Generate molecular descriptors from two-dimensional structures

Contact information
For more information, please contact Dr. Weida Tong at 870-543-7142 or weida.tong@fda.hhs.gov.

-Related Links
Decision Forest
Endocrine Disruptor Knowledge Base
MicroArray Quality Control (MAQC)

- Contact Us 870-543-7130
National Center for Toxicological Research
Food and Drug Administration
3900 NCTR Road
Jefferson, AR 72079

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