Personalized vaccines work, making them is the hard part The science behind personalized mRNA cancer vaccines is working. Building a different drug for every patient, at scale, is the real fight. Written byAndrea Corona

Personalized vaccines work, making them is the hard part The science behind personalized mRNA cancer vaccines is working. Building a different drug for every patient, at scale, is the real fight. Written byAndrea Corona https://www.drugdiscoverynews.com/personalized-vaccines-work-making-them-is-the-hard-part-17504?utm_campaign=DDN_Newsletter_Dose&utm_medium=email&_hsenc=p2ANqtz-9eS0EPQFrjU-Yg2KhEbctQkSQC34VQbtMFdNgjjeQN7m5gfruBGIAJ6bAKBges0B_7ijU1GWlzeb5wSfJSHu4gKTP0dA&_hsmi=444112830&utm_content=444112830&utm_source=hs_email Personalized mRNA cancer vaccines just cleared their biggest scientific hurdle. Recent Phase 3 data in melanoma showed the approach works in the clinic. But the possible implications of the findings are only as promising as the industry's ability to materialize them. "The payload works," Jeff Coller, RNA biologist at Johns Hopkins University, told DDN. "The carrier is the constraint." So here's the harder question nobody's fully answered yet, how do you actually make the thing? Every dose is a different molecule for a different person, so the industry can't just scale up the manufacturing playbook it built for COVID-19 vaccines. It has to build a new one.