Pain Sensitivity: Public Health & Genomic Insights - May 14, 2015

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Pain Sensitivity

Pain Sensitivity: Public Health & Genomic Insights - May 14, 2015

The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors
Wieskopf JS et al. Sci Trans Med, May 13, 2015

Emerging potassium channel targets for the treatment of pain.
Tsantoulas C et al. Curr Opin Support Palliat Care 2015 Jun (2) 147-54

The impact of genetic variation on sensitivity to opioid analgesics in patients with postoperative pain: a systematic review and meta-analysis.
Ren Zhen-Yu et al. Pain Physician 2015 Mar-Apr (2) 131-52

A discordant monozygotic-twin approach to potential risk factors for chronic widespread pain in females.
Burri A et al. Twin Res Hum Genet 2015 Apr (2) 188-97

Multimodal pain management and the future of a personalized medicine approach to pain.
Manworren RC et al. AORN J 2015 Mar (3) 308-14; quiz 315-8

Association between KCNJ6 (GIRK2) gene polymorphism rs2835859 and post-operative analgesia, pain sensitivity, and nicotine dependence.
Nishizawa D et al. J. Pharmacol. Sci. 2014 (3) 253-63

A review of the role of genetic testing in pain medicine.
Trescot AM et al. Pain Physician 2014 Sep-Oct (5) 425-45

Pain Sensitivity & Genetics: Recent Insights - August 21, 2014

Translational pain research: Lessons from genetics and genomics. 
Sulayman D. Dib-Hajj et al. Science Translational Medicine, August 13, 2014

Lost but making progress—Where will new analgesic drugs come from?
David Borsook et al. Science Translational Medicine, August 13, 2014

Pain genetics: past, present and future. 
Jeffrey S. Mogil, Cell (2012)

Human pain and genetics: some basics. 
Sabu James. British Journal of Pain (2013) 

Congenital insensitivity to pain, from the NIH Genetics Home Reference

Genes contributing to pain sensitivity in the normal population: An exome sequencing study. 
Frances M. K. Williams, PLOS Genetics (2012)

Search the NIH Genetic Testing Registry for genetic disorders and tests associated with chronic pain or pain insensitivity