New approach for Dravet syndrome therapy
Researchers at the Gladstone Institutes in San Francisco already discovered in earlier studies that decreasing the levels of the protein tau reduces abnormal brain activity in models of Alzheimer's disease. Now a study published in the "Annals of Neurology" showed that this reduction may also work for Dravet syndrome, a severe intractable form of childhood epilepsy.
In their study, senior author Lennart Mucke and his colleagues were able to suppress seizure activity and premature death in a mouse model, but also to improve cognitive and behavioural abnormalities that can accompany this syndrome.
"Our hope is that this approach will be broadly applicable to many different types of epilepsy," said first author Ania Gheyara. "The next steps are to develop tau-lowering therapeutics that could be used in humans and to evaluate their safety and efficacy in preclinical studies," said Mucke.
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