Xenotropic murine leukemia virus–related gammaretrovirus in respiratory tract

DOI: 10.3201/eid1606.100066
Suggested citation for this article: Fischer N, Schulz C, Stieler K, Hohn O, Lange C, Drosten C, et al. Xenotropic murine leukemia virus–related gammaretrovirus in respiratory tract. Emerg Infect Dis. 2010 Jun; [Epub ahead of print]

Xenotropic Murine Leukemia Virus–related Gammaretrovirus in Respiratory Tract
Nicole Fischer, Claudia Schulz, Kristin Stieler, Oliver Hohn, Christoph Lange, Christian Drosten, and Martin Aepfelbacher

Author affiliations: University Medical Center Hamburg-Eppendorf, Hamburg, Germany (N. Fischer, C. Schulz, K. Stieler, M. Aepfelbacher); Robert Koch-Institute, Berlin, Germany (O. Hohn); Leibniz-Center for Medicine and Biosciences, Borstel, Germany (C. Lange); and University of Bonn Medical Centre, Bonn, Germany (C. Drosten)
Xenotropic murine leukemia virus–related gammaretrovirus (XMRV) has been recently associated with prostate cancer and chronic fatigue syndrome. To identify nucleic acid sequences, we examined respiratory secretions by using PCR. XMRV-specific sequences were detected in 2%–3% of samples from 168 immunocompetent carriers and ≈10% of samples from 161 immunocompromised patients.

Xenotropic murine leukemia virus–related gammaretrovirus (XMRV) was originally discovered in tissue from patients with familial prostate cancer homozygous for a missense mutation in the RNase L gene, R462Q (1). Detection of viral nucleic acid in tissue sections of cancerous prostate glands and cloning of the viral integration sites confirmed XMRV as a bona fide human infection with a murine leukemia virus–related retrovirus (1). Whether XMRV is actively involved in prostate cancer tumorigenesis or whether it is just a bystander virus (2,3) remains unclear.

On the basis of its close homology (up to 94% nt identity) to endogenous and exogenous full-length sequences from Mus musculus mice (1), XMRV most likely originated in mice, although they are probably not the current reservoir of infection (4). Recent findings of XMRV sequences in up to 67% of peripheral blood mononuclear cells (PBMCs) of patients with chronic fatigue syndrome and in 3.4% of PBMCs of healthy controls raise the question whether XMRV...

open here to see the full-text in pdf of 7 pages:
http://www.cdc.gov/eid/content/16/6/pdfs/10-0066.pdf