CIENCIASMEDICASNEWS

jueves, 12 de noviembre de 2026

Acknowledging the Rare Navigating Diagnostic and Therapeutic Complexities in Rare Hematologic Disorders CME/CNE/CPE New Orleans Ernest N. Morial Convention Center Friday, December 11, 2026 | 3:30 pm - 5:00 pm CT

https://na.eventscloud.com/website/98255/ In this 90-minute symposium, some of the foremost experts in light-chain (AL) amyloidosis research and care will share actionable strategies for navigating complex challenges in this rare disease. Topics will include Diagnosis, staging, and stratifying: Improving timeliness and accuracy Treatment: Developing personalized, evidence-based plans Patient support: Helping patients navigate the long journey Workflows: Optimizing systems and teamwork The event speakers, involved in some of the most consequential trials in AL amyloidosis, will also examine key data for current treatments and novel approaches like fibril targeting. Register now to secure your spot, and prepare your questions for the live Q&A at the end of the session. Friday Satellite Symposium on Hematology, preceding the 68th ASH Annual Meeting and Exposition

Acknowledging the Rare Navigating Diagnostic and Therapeutic Complexities in Rare Hematologic Disorders CME/CNE/CPE New Orleans Ernest N. Morial Convention Center Friday, December 11, 2026 | 3:30 pm - 5:00 pm CT

https://na.eventscloud.com/website/98255/ This live, case-based symposium is designed to help healthcare professionals interpret and apply clinically relevant evidence to individualized treatment decisions for persons with hemophilia. The program will focus on persistent disease and treatment burden despite improved outcomes, the need to evaluate treatment success beyond bleeding rates, and the importance of tailoring care to patient-specific factors that drive burden across subgroups, including emerging data on nonfactor replacement prophylaxis options. Through expert-led discussion of real-world cases and audience polling, participants will examine how the expanding availability of novel prophylactic options—including factor replacement therapies, factor VIIIa mimetics, rebalancing agents, and gene therapies—offer new strategies for optimizing not only bleed rates but long-term joint health, treatment burden, and quality of life for people with hemophilia. Friday Satellite Symposium on Hematology, preceding the 68th ASH Annual Meeting and Exposition

Viewpoint: ‘Sanitation and nutrition not vaccines’: The rejectionists’ latest false substitute for staying up to date on your shots Jess Steier | November 12, 2026

https://geneticliteracyproject.org/2026/11/12/viewpoint-sanitation-and-nutrition-not-vaccines-the-rejectionists-latest-false-substitute-for-staying-up-to-date-on-your-shots/ Has anyone ever heard matzoh ball soup referred to as Jewish penicillin? I’ve called it that my whole life. It was the first thing my mom made whenever I was sick, a pot chock full of veggies, herbs, and protein (and the matzoh balls!). It was good for my body and good for my soul, a warm generational hug in a bowl. Of course, we know soup isn’t actually penicillin, which is an antibiotic (and I was usually eating it for a cold or the flu, which are caused by viruses that antibiotics can’t treat anyway). That soup nourished me and comforted me while my body fought off whatever I had, but it couldn’t keep me from catching the next bug going around school.

Clonal haematopoiesis: a major link in the cancer–Alzheimer's disease inverse correlation eBioMedicine (+...)

Clonal haematopoiesis: a major link in the cancer–Alzheimer's disease inverse correlation eBioMedicine https://www.thelancet.com/journals/ebiom/issue/vol133nonull/PIIS2352-3964(26)X2009-6 First characterised in 2014, clonal haematopoiesis is a condition defined by the expansion of a haematopoietic stem cell clone, and its progeny, carrying somatic mutations in leukaemia-associated genes. Sensitive sequencing techniques show that clonal haematopoiesis, irrespective of clone size, becomes near-universal with ageing. A related term, clonal haematopoiesis of indeterminate potential (CHIP), describes the presence of a clone that has expanded to a variant allele fraction of ≥2% (and as a result ≥4% of nucleated blood cells) and is considered clinically significant. As expected, CHIP is a strong risk factor for subsequent haematologic cancers (hazard ratio 12·9 [95% CI 5·8–28·7]). Incident coronary heart disease (2·0 [1·2–3·4]), ischaemic stroke (2·6 [1·4–4·8]), and all-cause mortality (1·4 [1·1–1·8]) also increased. Mechanistic studies in animal models suggest that altered gene expression and changes in the function of circulating mutant macrophages are likely to contribute to the more rapid expansion of atherosclerotic lesions in the presence of CHIP.

Move over BMI: new obesity definition is better for predicting your health A fresh approach considers waist circumference, rather than just weight and height, providing a more accurate classification. By Mariana Lenharo

Move over BMI: new obesity definition is better for predicting your health A fresh approach considers waist circumference, rather than just weight and height, providing a more accurate classification. By Mariana Lenharo https://www.nature.com/articles/d41586-026-03636-5 Clinicians have debated for years whether body mass index (BMI) — a metric derived from a person’s height and weight — is the best way to define and diagnose obesity. Now, an approach that measures waist circumference and focuses more closely on excess body fat has proved to be better than BMI at predicting a person’s risk of death.

RSV vaccines slash infections: data show jabs’ staggering success against dangerous virus Vaccines and monoclonal antibody injections are cutting hospitalizations for the respiratory virus. By Liam Drew

RSV vaccines slash infections: data show jabs’ staggering success against dangerous virus Vaccines and monoclonal antibody injections are cutting hospitalizations for the respiratory virus. By Liam Drew https://www.nature.com/articles/d41586-026-03573-3 “Something’s wrong with the data. There are too few people in hospitals” with respiratory syncytial virus (RSV), epidemiologist Caroline Klint Johannesen recalls a colleague remarking while analysing Danish health records for last winter.

New culprit in early Alzheimer’s: Blood–brain barrier blocks protective proteins The brain relies on crucial proteins to maintain neurons. This system is disrupted in mice with neurological disease. By Mohana Basu

New culprit in early Alzheimer’s: Blood–brain barrier blocks protective proteins The brain relies on crucial proteins to maintain neurons. This system is disrupted in mice with neurological disease. By Mohana Basu For decades, scientists thought of the blood–brain barrier as an impenetrable layer. Overtime that view has changed, as researchers realized the barrier was more permeable than first thought. Now a team have catalogued almost 100 proteins that can pass through it to maintain brain health.1 https://www.nature.com/articles/d41586-026-03655-2?utm_source=Live+Audience&utm_campaign=21e610d5d7-nature-briefing-daily-20261111&utm_medium=email&utm_term=0_-33f35e09ea-50432164 Brain-protein highway clogs in Alzheimer’s Researchers have catalogued almost 100 proteins that get a free pass through the blood–brain barrier to maintain the health of neurons. Most of these proteins were produced in distant organs, particularly the liver. The team found that the transport of some of these proteins is disrupted in mice with a brain disease that mimics early-stage Alzheimer’s disease. The work suggests that the brain actively imports the proteins it needs to stay healthy, and that the breakdown of that transport drives the dysfunction seen in neurodegenerative disease, says neuroscientist and study co-author Andrew Yang.

Bladder Cancer Tumor Board: Optimizing Treatment Selection and Therapeutic Tolerability Authors: Andrea Necchi, MD; Thomas Powles, MBBS, MRCP, MD; Gaia Latini, MSN, RN

https://www.medscape.org/viewarticle/bladder-cancer-tumor-board-optimizing-treatment-selection-2026a1000r3y?page=1&src=mkmcmr_driv_stan_mscpedu_261111-OUS-HONC-bladder-cancer-tumor-board-optimizing-treatment-selection-2026a1000r3y-cta&uac=148436CN

Refining Adjuvant Therapy in HR-Positive/HER2-Negative Early Breast Cancer: Personalizing Care in the CDK4/6 Inhibitor Era Authors: Nadia Harbeck, MD, PhD; Frédérique Penault-Llorca, MD; Giampaolo Bianchini, MD; Henry Cain, MBChB, FRCS, MD; Janice Walshe, MB BCh, BAO, MRCPI

https://www.medscape.org/viewarticle/refining-adjuvant-therapy-hr-positive-her2-negative-early-2026a1000ysl?page=1&uac=148436CN&src=mkmcmr_driv_stan_mscpedu_261111-OUS-HONC-refining-adjuvant-therapy-hr-positive-her2-negative-early-2026a1000ysl-cta

Why We Need to End the 'Overall Survival Obsession' (+++++)

Why We Need to End the 'Overall Survival Obsession' https://www.medscape.com/viewarticle/why-we-need-end-overall-survival-obsession-2026a10014gx?ecd=wnl_edit_tpal_etid8893653&uac=148436CN&impID=8893653 Tau Accumulates More Than Twice as Fast in Early-Onset AD https://www.medscape.com/viewarticle/tau-accumulates-more-than-twice-fast-early-onset-ad-2026a100170o?ecd=wnl_edit_tpal_etid8893653&uac=148436CN&impID=8893653 Fast Five Quiz: Identify and Treat Crohn's Disease https://reference.medscape.com/viewarticle/fast-five-quiz-identify-and-treat-crohns-disease-2025a1000ec7?ecd=wnl_edit_tpal_etid8893653&uac=148436CN&impID=8893653 Is the Rectal Exam Useful in Cauda Equina Syndrome? https://www.medscape.com/viewarticle/rectal-exam-useful-cauda-equina-syndrome-2026a10016ky?ecd=wnl_edit_tpal_etid8893653&uac=148436CN&impID=8893653 Psychiatrists Are Losing Autonomy. How Can We Reclaim It? https://www.medscape.com/viewarticle/psychiatrists-are-losing-autonomy-how-can-we-reclaim-it-2026a100164o?ecd=wnl_edit_tpal_etid8893653&uac=148436CN&impID=8893653

Medscape NOW! Beyond the Itch: Recognizing and Treating Genital Lichen Sclerosus Authors: Blessing Ajayi, PA-C; Amanda Jett, PharmD, BCACP, CHCP

https://www.medscape.org/viewarticle/medscape-now-beyond-itch-recognizing-and-treating-genital-2026a10016h9?page=1

Oncology News: Can Chronic Stress Influence Cancer Progression? (+...) (+...) (+...) (+...)

Oncology News Can Chronic Stress Influence Cancer Progression? Stress-related hormonal and immune signals may interact with tumor biology, but current evidence does not establish that psychological stress causes cancer progression. Medscape News Europe, November 12, 2026 https://www.medscape.com/index/list_13474_0 Oncology Perspective Why We Need to End the 'Overall Survival Obsession' Waiting for OS delays vital care. Dr Mark Kris explains why prioritizing progression-free survival is both better medicine and faster drug development. Medscape Oncology, November 10, 2026 https://www.medscape.com/index/list_13293_0 Oncology Conferences ESMO 2026 Read clinically focused news coverage of key developments from ESMO 2026. Medscape Oncology, October 23, 2026 https://www.medscape.com/index/list_339_0 Oncology Cases & Quizzes Quiz: Recognizing and Diagnosing CLL Can you recognize typical CLL findings and interpret its diagnostic and staging features? Test your knowledge with five questions. Medscape Reference, November 11, 2026 https://www.medscape.com/index/list_12039_0

FDA Approves Pimicotinib for Symptomatic TGCT

https://www.medscape.com/viewarticle/fda-approves-pimicotinib-symptomatic-tgct-2026a10016zp?ecd=WNL_trdalrt_pos1_ous_261112_etid8894264&uac=148436CN&impID=8894264 The FDA has approved pimicotinib (Pimjetmi, EMD Serono) for treating patients with symptomatic tenosynovial giant cell tumors (TGCTs) for which surgical resection will potentially cause worsening functional limitations or severe morbidity. Pimicotinib, a CSF-1R TKI, joins two others already on the US market for the indication: vimseltinib and pexidartinib.

Medscape Congenital Heart Disease Yasmine S. Ali, MD, MSci

https://reference.medscape.com/p11/congenital-heart-disease-2026a100128d?ecd=mkm_ret_261112_mscpmrk-OUS_DisReferences_etid8886540&uac=148436CN&impID=8886540 Tetralogy of Fallot consists, as the name suggests, of four structural congenital heart defects: a malalignment ventricular septal defect, right ventricular outflow tract obstruction (also known as subpulmonic stenosis), an overriding aorta, and RV hypertrophy, all consequences of anterocephalad deviation of the outlet septum. It is the most common cyanotic congenital heart lesion, with a birth prevalence of 3-5 per 10,000 live births, and roughly 20% of cases occur with a genetic syndrome, most commonly 22q11.2 deletion syndrome.[1,2] Because most patients now survive childhood repair, tetralogy of Fallot in adults is defined less by the original anatomy than by the aftereffects of treatment: Chronic pulmonary regurgitation is nearly universal after transannular patch repair and drives progressive RV dilation, exercise intolerance, arrhythmia, and sudden cardiac death. Surveillance includes serial cardiac MRI, exercise testing, and rhythm monitoring, with surgical or transcatheter pulmonary valve replacement timed to preempt irreversible RV dysfunction.

Diagnosis and Treatment of Cervical Cancer Sarah A. Ackroyd, MD, MPH

https://reference.medscape.com/p11/diagnosis-and-treatment-cervical-cancer-2026a10013lq?ecd=mkm_ret_261112_mscpmrk-OUS_DisReferences_etid8886540&uac=148436CN&impID=8886540 Cervical cancer is the fourth most common cancer among women worldwide and is the 22nd most common cancer in the United States, representing 0.6% of new cancer cases and 0.7% of deaths nationally. In the US in 2026, there were an estimated 13,490 new cases and 4200 deaths. Cervical cancer also affects younger women; it's the second-leading cause of cancer death in those aged 20-39 years and the fourth-leading cause of cancer death for those aged 40-49 years.[1]

Physical Symptoms of Stress Nameera Temkar, MD

https://reference.medscape.com/p11/physical-symptoms-stress-2026a100128e?ecd=mkm_ret_261112_mscpmrk-OUS_DisReferences_etid8886540&uac=148436CN&impID=8886540 Chronic physical and/or psychological stress are well known to have a deleterious effect on mental health. Physiologic stress responses can also lead to a host of physical symptoms affecting virtually every organ system in the body.

Diagnosis and Management of Hypertension in Primary Care Source: Department of Veterans Affairs, Department of Defense

https://reference.medscape.com/cc2/p10/diagnose-manage-hypertension-primary-care-va-dod-guideline-2026a10015ud?ecd=mkm_ret_261112_mscpmrk-OUS_DisReferences_etid8886540&uac=148436CN&impID=8886540 Elevated BP is an established risk factor for conditions like CAD, HF, stroke, peripheral vascular disease, CKD, and cognitive decline, and conditions such as CKD and/or diabetes can elevate hypertensive risk. Hypertension, or pathologically elevated BP, is a silent asymptomatic condition, which is considered a modifiable risk factor for CVD. BP progressively increases with advancing age, and the prevalence of hypertension varies by age, sex, and ethnicity. In 2026, VA/DOD published an update to its clinical guideline on hypertension; this Medscape summary of the guideline covers diagnosis, monitoring, and...

Diagnosis, Treatment, and Monitoring of Long-Chain Fatty Acid Oxidation Disorders Source: International Consensus Group

https://reference.medscape.com/cc2/p10/long-chain-fatty-acid-oxidation-lc-faod-guidelines-2026a10014ez?ecd=mkm_ret_261112_mscpmrk-OUS_DisReferences_etid8886540&uac=148436CN&impID=8886540 This Medscape guideline summary includes recommendations from an international consensus guideline on LC-FAODs, a series of inherited defects of mitochondrial β-oxidation that impair energy generation during fasting or metabolic stress. The LC-FAODs addressed in this guideline are CPT1a deficiency, CACT deficiency, CPT2 deficiency, VLCAD deficiency, LCHAD deficiency, and TFP/MTP deficiency. For further information, including grading of recommendations and discussions of the evidence base, refer to the full guideline.

Evaluation, Diagnosis, and Management of Headache Source: Department of Veterans Affairs, Department of Defense; Medically Reviewed by Dr Yasmine Ali

https://reference.medscape.com/cc2/p10/va-dod-headache-guideline-2026a100125n?ecd=mkm_ret_261112_mscpmrk-OUS_DisReferences_etid8886540&uac=148436CN&impID=8886540 The 2023 VA/DoD guideline provides recommendations on the evaluation and management of headache. This Medscape guideline summary covers initial evaluation, differentiation of primary and secondary headache, diagnostic criteria for TTH, migraine, and cluster headache, three secondary headache types (cervicogenic headache, PTH, and MOH), and treatment with medications, procedures, neuromodulation, and nonpharmacologic approaches.