Single-cell sequencing data shows how pancreatic cancer tumors evolve to resist therapy The multi-omics data on nearly half a million tumor cells showed that even cells with almost identical genetic makeup can show radically different behavior. Written byAllison Whitten, PhD

Single-cell sequencing data shows how pancreatic cancer tumors evolve to resist therapy The multi-omics data on nearly half a million tumor cells showed that even cells with almost identical genetic makeup can show radically different behavior. Written byAllison Whitten, PhD https://www.drugdiscoverynews.com/single-cell-sequencing-data-shows-how-pancreatic-cancer-tumors-evolve-to-resist-therapy-17603 One abnormal cell is all it takes to kickstart cancer development. The cell acquires genetic mutations and then multiplies uncontrollably into clone cells that share nearly identical genes. But, according to new research led by Diane Simeone of University of California, San Diego and Aristotelis Tsirigos’ of New York University. these clone cells don't behave like clones in the very aggressive pancreatic ductal adenocarcinoma (PDAC). In a new paper published in Nature Genetics, the researchers used single-cell RNA sequencing on 443,451 cells taken from 65 PDAC tumors, with 11 tumors that also had matched spatial transcriptomics. Their team showed that the clone cells behaved differently from one another, with some edging out others in their ability to resist treatments and some being more likely to spread and metastasize.