Metaflammation Explained: How Obesity, Diabetes, and Aging Are Connected

https://www.news-medical.net/health/Metaflammation-Explained-How-Obesity-Diabetes-and-Aging-Are-Connected.aspx What happens when expanding fat tissue changes immune activity? Researchers are examining the signals connecting nutrient excess, organ dysfunction, and age-related disease. Obesity, a highly prevalent condition throughout the world, develops through interactions among genetic, environmental, behavioral, and neuroendocrine factors. Sustained nutrient excess can promote adipose tissue expansion by enlarging existing adipocytes and, in some settings, increasing adipocyte number. Dysfunctional expansion can trigger ‘metaflammation,’ a chronic, low-grade inflammatory response associated with metabolic dysfunction.1,3