Type 1 Plasminogen Deficiency Overview by Madaline Spencer| Published on: Mar 13, 2026

https://checkrare.com/type-1-plasminogen-deficiency-overview/ Amy Shapiro, MD, a pediatric hematologist and the Medical Director and CEO of the Indiana Hemophilia and Thrombosis Center in Indianapolis, provides CheckRare an overview on type 1 plasminogen deficiency (PLGD-1). Plasminogen Deficiency: Fibrin Accumulation and Its Effects on Patients Plasminogen is a precursor protein that is converted into plasmin. Plasmin is crucial to break down fibrin, the main protein component of blood clots. When the body does not produce sufficient plasminogen or does not produce adequate active plasminogen, fibrin can accumulate in mucous membranous areas throughout the body.