Transdermal therapy restores anti-tumor immunity in bladder cancer models Preclinical data show a first-in-class transdermal bicarbonate therapy increases tumor pH, reactivates T cells and slows bladder tumor growth in mice.

https://www.drugdiscoverynews.com/transdermal-therapy-restores-anti-tumor-immunity-in-bladder-cancer-models-17130 Extracellular acidity is a common feature of many solid tumors, similar to hypoxia. Increased metabolic rates, higher glycolysis and inadequate vasculature all contribute to the accumulation of acid in the tumor microenvironment (TME). This aspect is also one of their most effective defenses.