Is prednisone or dexamethasone preferred for stress dosing in adrenal insufficiency? (Medscape AI)

https://www.medscape.com/ai-search?query=Is%20prednisone%20or%20dexamethasone%20preferred%20for%20stress%20dosing%20in%20adrenal%20insufficiency%3F&ecd=wnl_tp10_daily_251216_MSCPEDIT_etid7959585&uac=148436CN&impID=7959585 In patients with adrenal insufficiency who require stress-dose glucocorticoids (eg, during acute illness, surgery, or suspected adrenal crisis), parenteral hydrocortisone remains the mainstay of therapy because of its combined glucocorticoid and mineralocorticoid effects. However, when urgent cortisol measurement or a cosyntropin stimulation test is planned, dexamethasone is the preferred empiric agent, since it does not cross-react in standard cortisol assays. By contrast, prednisone (or its active metabolite prednisolone) is typically reserved for maintenance oral replacement and is not routinely used for acute stress dosing.