Study defines major genetic form of Alzheimer’s disease

https://www.nih.gov/news-events/nih-research-matters/study-defines-major-genetic-form-alzheimer-s-disease A small portion of early-onset Alzheimer’s disease (AD) cases are known to be genetically determined. These include early-onset autosomal dominant AD and Down syndrome-associated AD. In these conditions, almost everyone with the associated gene variants will develop the disease. Symptoms typically begin between 40 and 60 years of age. Clinical, pathological, and biomarker changes follow a predictable sequence.