Mast cells control lung type 2 inflammation via prostaglandin E2-driven soluble ST2

https://www.cell.com/immunity/abstract/S1074-7613(24)00254-1?utm_term=&utm_campaign=60800870&utm_medium=email&utm_content=&utm_source=govdelivery Allergy news: NIAID-funded researchers identified a novel mechanism by which immune cells known as mast cells may protect from allergic inflammation, such as that seen in asthma and allergic disease. They found that mast cells use a unique pathway to reduce allergy-related inflammation in mice, and showed that this mechanism is likely similar in human allergic disease. This finding is surprising because mast cells are primarily believed to cause allergic reactions rather than protect from them. This function of mast cells could inform new approaches to treating allergy and asthma in people. The findings were published in Immunity.