domingo, 30 de agosto de 2020

Translating the microbiome in health and disease

Translating the microbiome in health and disease



Translating the microbiome in health and disease

Guest Editor: Ramnik Xavier

New Content ItemGenome Medicine is pleased to present a special issue entitled 'Translating the microbiome in health and disease,' guest edited by Dr. Ramnik Xavier of the Broad Institute of MIT and Harvard. Research efforts exploring the human microbiome using large-scale metagenomics and multi-omics have rapidly expanded, facilitating characterization of microbiome composition, dynamics, variation, and function in health and disease. Such studies are increasing our understanding of the microbiome’s impact on the immune response and other physiological processes, and further enabling a shift from correlation to causation, with emerging insights into how this data can be utilized for diagnostic and therapeutic benefit. These efforts also highlight the need for the standardization of microbiome research protocols in order to accelerate progress through collaborative research. This special issue aims to capture recent insights into all aspects of the human microbiome in health and disease including standards for microbiome analyses in basic and clinical research, microbiome analysis tools and technologies, metagenomics and integrative multi-omics, antibiotics and the microbiome, microbial biochemistry and diet, translational interventions, and host-microbiome interactions. 

This collection of articles has not been sponsored and articles will undergo the journal’s standard peer-review process. The Guest Editor declares that they have no competing interests. Guest Editors serve an advisory role to guide the scope of the special issue and commissioned content; final editorial decisions lie with the Editor.
  1. Although the microbiome is established as an important regulator of health and disease, the role of viruses that inhabit asymptomatic humans (collectively, the virome) is less defined. While we are still chara...
    Authors:Fatemeh Adiliaghdam and Kate L. Jeffrey
    Citation:Genome Medicine 2020 12:66
    Content type:Comment
     
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  2. There is increasing evidence that the intestinal microbiota plays a crucial role in the maturation of the immune system and the prevention of diseases during childhood. Early-life short-course antibiotic use m...
    Authors:Ceren Ozkul, Victoria E. Ruiz, Thomas Battaglia, Joseph Xu, Claire Roubaud-Baudron, Ken Cadwell, Guillermo I. Perez-Perez and Martin J. Blaser
    Citation:Genome Medicine 2020 12:65
    Content type:Research
     
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  3. Dietary glycans, widely used as food ingredients and not directly digested by humans, are of intense interest for their beneficial roles in human health through shaping the microbiome. Characterizing the consi...
    Authors:Richard Creswell, Jie Tan, Jonathan W. Leff, Brandon Brooks, Michael A. Mahowald, Ruth Thieroff-Ekerdt and Georg K. Gerber
    Citation:Genome Medicine 2020 12:59
    Content type:Research
     
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  4. Populations of closely related microbial strains can be simultaneously present in bacterial communities such as the human gut microbiome. We recently developed a de novo genome assembly approach that uses read...
    Authors:Soumaya Zlitni, Alex Bishara, Eli L. Moss, Ekaterina Tkachenko, Joyce B. Kang, Rebecca N. Culver, Tessa M. Andermann, Ziming Weng, Christina Wood, Christine Handy, Hanlee P. Ji, Serafim Batzoglou and Ami S. Bhatt
    Citation:Genome Medicine 2020 12:50
    Content type:Research
     
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  5. Cystic fibrosis is the most common autosomal recessive genetic disease in Caucasians. It is caused by mutations in the CFTR gene, leading to poor hydration of mucus and impairment of the respiratory, digestive, a...
    Authors:Gargi Dayama, Sambhawa Priya, David E. Niccum, Alexander Khoruts and Ran Blekhman
    Citation:Genome Medicine 2020 12:12
    Content type:Research
     
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