Comprehensive analysis of diverse low-grade neuroepithelial tumors with FGFR1 alterations reveals a distinct molecular signature of rosette-forming glioneuronal tumor
The FGFR1 gene encoding fibroblast growth factor receptor 1 has emerged as a frequently altered oncogene in the pathogenesis of multiple low-grade neuroepithelial tumor (LGNET) subtypes including pilocytic astroc...Acta Neuropathologica Communications 2020 8:151Trans-synaptic and retrograde axonal spread of Lewy pathology following pre-formed fibril injection in an in vivo A53T alpha-synuclein mouse model of synucleinopathy
It is necessary to develop an understanding of the specific mechanisms involved in alpha-synuclein aggregation and propagation to develop disease modifying therapies for age-related synucleinopathies, includin...Acta Neuropathologica Communications 2020 8:150Regional correlation of biochemical measures of amyloid and tau phosphorylation in the brain
Alzheimer’s disease (AD) neuropathologic change is characterized by amyloid plaques and neurofibrillary tangles (NFTs) that consist of aggregated amyloid beta (Abeta) and hyperphosphorylated tau proteins (p-ta...Acta Neuropathologica Communications 2020 8:149Unclassified four-repeat tauopathy associated with familial parkinsonism and progressive respiratory failure
We describe an autopsied patient with familial parkinsonism and unclassified four repeat-tau (4R-tau) aggregation. She presented with bradykinesia, truncal dystonia, and mild amnesia at the age of 61 and then ...Acta Neuropathologica Communications 2020 8:148Neuronophagia and microglial nodules in a SARS-CoV-2 patient with cerebellar hemorrhage
We document the neuropathologic findings of a 73-year old man who died from acute cerebellar hemorrhage in the context of relatively mild SARS-CoV2 infection. The patient developed sudden onset of headache, na...Acta Neuropathologica Communications 2020 8:147Acute brain injuries trigger microglia as an additional source of the proteoglycan NG2
NG2 is a type I transmembrane glycoprotein known as chondroitin sulfate proteoglycan 4 (CSPG4). In the healthy central nervous system, NG2 is exclusively expressed by oligodendrocyte progenitor cells and by va...Acta Neuropathologica Communications 2020 8:146New somatic TERT promoter variants enhance the Telomerase activity in Glioblastoma
The catalytic activity of human Telomerase Reverse Transcriptase (TERT) compensates for the loss of telomere length, eroded during each cell cycle, to ensure a correct division of stem and germinal cells. In h...Acta Neuropathologica Communications 2020 8:145Innate immune response in neuronopathic forms of Gaucher disease confers resistance against viral-induced encephalitis
Both monogenic diseases and viral infections can manifest in a broad spectrum of clinical phenotypes that range from asymptomatic to lethal, suggesting that other factors modulate disease severity. Here, we ex...Acta Neuropathologica Communications 2020 8:144Increased levels of Stress-inducible phosphoprotein-1 accelerates amyloid-β deposition in a mouse model of Alzheimer’s disease
Molecular chaperones and co-chaperones, which are part of the protein quality control machinery, have been shown to regulate distinct aspects of Alzheimer’s Disease (AD) pathology in multiple ways. Notably, th...Acta Neuropathologica Communications 2020 8:143Ovine congenital progressive muscular dystrophy (OCPMD) is a model of TNNT1 congenital myopathy
Ovine congenital progressive muscular dystrophy (OCPMD) was first described in Merino sheep flocks in Queensland and Western Australia in the 1960s and 1970s. The most prominent feature of the disease is a dis...Acta Neuropathologica Communications 2020 8:142Assessment of radial glia in the frontal lobe of fetuses with Down syndrome
Down syndrome (DS) occurs with triplication of human chromosome 21 and is associated with deviations in cortical development evidenced by simplified gyral appearance and reduced cortical surface area. Radial g...Acta Neuropathologica Communications 2020 8:141Defining novel functions for cerebrospinal fluid in ALS pathophysiology
Despite the considerable progress made towards understanding ALS pathophysiology, several key features of ALS remain unexplained, from its aetiology to its epidemiological aspects. The glymphatic system, which...Acta Neuropathologica Communications 2020 8:140BRAF V600E mutation mediates FDG-methionine uptake mismatch in polymorphous low-grade neuroepithelial tumor of the young
We present a case of a 14-year old boy with tumor-associated refractory epilepsy. Positron emission tomography imaging demonstrated a region with heterogeneous high 11C-methionine uptake and a region with homogen...Acta Neuropathologica Communications 2020 8:139RNA-recognition motif in Matrin-3 mediates neurodegeneration through interaction with hnRNPM
Amyotrophic lateral sclerosis (ALS) is an adult-onset, fatal neurodegenerative disease characterized by progressive loss of upper and lower motor neurons. While pathogenic mutations in the DNA/RNA-binding prot...Acta Neuropathologica Communications 2020 8:138Tau reduction in aged mice does not impact Microangiopathy
Microangiopathy, including proliferation of small diameter capillaries, increasing vessel tortuosity, and increased capillary blockage by leukocytes, was previously observed in the aged rTg4510 mouse model. Si...Acta Neuropathologica Communications 2020 8:137Single-cell mass cytometry reveals complex myeloid cell composition in active lesions of progressive multiple sclerosis
Myeloid cells contribute to inflammation and demyelination in the early stages of multiple sclerosis (MS), but it is still unclear to what extent these cells are involved in active lesion formation in progress...Acta Neuropathologica Communications 2020 8:136Lipid-specific IgMs induce antiviral responses in the CNS: implications for progressive multifocal leukoencephalopathy in multiple sclerosis
Progressive multi-focal leukoencephalopathy (PML) is a potentially fatal encephalitis caused by JC polyomavirus (JCV). PML principally affects people with a compromised immune system, such as patients with mul...Acta Neuropathologica Communications 2020 8:135- Acta Neuropathologica Communications 2020 8:134
Prominent microglial inclusions in transgenic mouse models of α-synucleinopathy that are distinct from neuronal lesions
Alpha-synucleinopathies are a group of progressive neurodegenerative disorders, characterized by intracellular deposits of aggregated α-synuclein (αS). The clinical heterogeneity of these diseases is thought t...Acta Neuropathologica Communications 2020 8:133P53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer’s disease
The transcription factor, p53, is critical for many important cellular functions involved in genome integrity, including cell cycle control, DNA damage response, and apoptosis. Disruption of p53 results in a w...Acta Neuropathologica Communications 2020 8:132Demonstrating a reduced capacity for removal of fluid from cerebral white matter and hypoxia in areas of white matter hyperintensity associated with age and dementia
White matter hyperintensities (WMH) occur in association with dementia but the aetiology is unclear. Here we test the hypothesis that there is a combination of impaired elimination of interstitial fluid from t...Acta Neuropathologica Communications 2020 8:131Co-expression of NMDA-receptor subunits NR1, NR2A, and NR2B in dysplastic neurons of teratomas in patients with paraneoplastic NMDA-receptor-encephalitis: a retrospective clinico-pathology study of 159 patients
To comprehensively describe the pathological features of neurons in patients with ovarian teratomas and paraneoplastic anti-NMDAR encephalitis (anti-NMDARE), emphasizing on NMDA-receptor expression and infiltr...Acta Neuropathologica Communications 2020 8:130Microglia depletion diminishes key elements of the leukotriene pathway in the brain of Alzheimer’s Disease mice
Leukotrienes (LTs) contribute to the neuropathology of chronic neurodegenerative disorders including Alzheimer’s Disease (AD), where they mediate neuroinflammation and neuronal cell-death. In consequence, bloc...Acta Neuropathologica Communications 2020 8:129Clinical, radiological and molecular characterization of intramedullary astrocytomas
Intramedullary astrocytomas (IMAs) are rare tumors, and few studies specific to the molecular alterations of IMAs have been performed. Recently, KIAA1549-BRAF fusions and the H3F3A p.K27M mutation have been descr...Acta Neuropathologica Communications 2020 8:128Upregulating β-hexosaminidase activity in rodents prevents α-synuclein lipid associations and protects dopaminergic neurons from α-synuclein-mediated neurotoxicity
Sandhoff disease (SD) is a lysosomal storage disease, caused by loss of β-hexosaminidase (HEX) activity resulting in the accumulation of ganglioside GM2. There are shared features between SD and Parkinson’s di...Acta Neuropathologica Communications 2020 8:127Intramuscular injection of vectorized-scFvMC1 reduces pathological tau in two different tau transgenic models
With evidence supporting the prion-like spreading of extracellular tau as a mechanism for the initiation and progression of Alzheimer’s disease (AD), immunotherapy has emerged as a potential disease-modifying ...Acta Neuropathologica Communications 2020 8:126Distinct tissue injury patterns in juvenile dermatomyositis auto-antibody subgroups
Juvenile dermatomyositis (JDM) can be classified into clinical serological subgroups by distinct myositis-specific antibodies (MSAs). It is incompletely understood whether different MSAs are associated with di...Acta Neuropathologica Communications 2020 8:125A comprehensive DNA panel next generation sequencing approach supporting diagnostics and therapy prediction in neurooncology
Recent updates in the classification of central nervous system (CNS) tumors have increased the need for molecular testing. Assessment of multiple alterations in parallel, complex combinations of gene sequence ...Acta Neuropathologica Communications 2020 8:124Correction to: Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology
An amendment to this paper has been published and can be accessed via the original article.Acta Neuropathologica Communications 2020 8:123The original article was published in Acta Neuropathologica Communications 2017 5:46The carboxyl termini of RAN translated GGGGCC nucleotide repeat expansions modulate toxicity in models of ALS/FTD
An intronic hexanucleotide repeat expansion in C9ORF72 causes familial and sporadic amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). This repeat is thought to elicit toxicity through RNA med...Acta Neuropathologica Communications 2020 8:122Correction to: Different aspects of Alzheimer’s disease-related amyloid β-peptide pathology and their relationship to amyloid positron emission tomography imaging and dementia
An amendment to this paper has been published and can be accessed via the original article.Acta Neuropathologica Communications 2020 8:121The original article was published in Acta Neuropathologica Communications 2019 7:178BCAS1-positive immature oligodendrocytes are affected by the α-synuclein-induced pathology of multiple system atrophy
Multiple system atrophy (MSA) is pathologically characterized by the presence of fibrillar α-synuclein-immunoreactive inclusions in oligodendrocytes. Although the myelinating process of oligodendrocytes can be...Acta Neuropathologica Communications 2020 8:120Different effects of constitutive and induced microbiota modulation on microglia in a mouse model of Alzheimer’s disease
It was recently revealed that gut microbiota promote amyloid-beta (Aβ) burden in mouse models of Alzheimer’s disease (AD). However, the underlying mechanisms when using either germ-free (GF) housing conditions...Acta Neuropathologica Communications 2020 8:119Phosphorylated Aβ peptides in human Down syndrome brain and different Alzheimer’s-like mouse models
The deposition of neurotoxic amyloid-β (Aβ) peptides in extracellular plaques in the brain parenchyma is one of the most prominent neuropathological features of Alzheimer’s disease (AD), and considered to be c...Acta Neuropathologica Communications 2020 8:118Towards an improved early diagnosis of neurodegenerative diseases: the emerging role of in vitro conversion assays for protein amyloids
Tissue accumulation of abnormal aggregates of amyloidogenic proteins such as prion protein, α-synuclein, and tau represents the hallmark of most common neurodegenerative disorders and precedes the onset of sym...Acta Neuropathologica Communications 2020 8:117Loss of Tdp-43 disrupts the axonal transcriptome of motoneurons accompanied by impaired axonal translation and mitochondria function
Protein inclusions containing the RNA-binding protein TDP-43 are a pathological hallmark of amyotrophic lateral sclerosis and other neurodegenerative disorders. The loss of TDP-43 function that is associated w...Acta Neuropathologica Communications 2020 8:116A dual-genotype oligoastrocytoma with histologic, molecular, radiological and time-course features
A case of a true dual-genotype IDH-mutant oligoastrocytoma with two different cell types within a single mass in a young woman is presented. Imaging findings of the left frontal infiltrating glioma predicted the ...Acta Neuropathologica Communications 2020 8:115Meningioma cells express primary cilia but do not transduce ciliary Hedgehog signals
Meningiomas are the most common primary intracranial tumors, but treatment options for meningioma patients are limited due to incomplete understanding of tumor biology. A small percentage of meningiomas harbor...Acta Neuropathologica Communications 2020 8:114Orbital Rosai-Dorfman disease initially diagnosed as IgG4-related disease: a case report
Inflammatory orbital lesions include a broad list of diagnoses, many of them with overlapping clinical and radiographic features. They often present a diagnostic conundrum, even to the most experienced orbital...Acta Neuropathologica Communications 2020 8:113- Acta Neuropathologica Communications 2020 8:112
Global activation of oncogenic pathways underlies therapy resistance in diffuse midline glioma
Diffuse midline gliomas (DMGs) are aggressive pediatric brain tumors with dismal prognosis due to therapy-resistant tumor growth and invasion. We performed the first integrated histologic/genomic/proteomic ana...Acta Neuropathologica Communications 2020 8:111C9orf72-associated SMCR8 protein binds in the ubiquitin pathway and with proteins linked with neurological disease
A pathogenic GGGCCC hexanucleotide expansion in the first intron/promoter region of the C9orf72 gene is the most common mutation associated with amyotrophic lateral sclerosis (ALS). The C9orf72 gene product forms...Acta Neuropathologica Communications 2020 8:110The unfolded protein response is activated in the olfactory system in Alzheimer’s disease
Olfactory dysfunction is an early and prevalent symptom of Alzheimer’s disease (AD) and the olfactory bulb is a nexus of beta-amyloid plaque and tau neurofibrillary tangle (NFT) pathology during early AD progr...Acta Neuropathologica Communications 2020 8:109Fyn depletion ameliorates tauP301L-induced neuropathology
The Src family non-receptor tyrosine kinase Fyn has been implicated in neurodegeneration of Alzheimer’s disease through interaction with amyloid β (Aβ). However, the role of Fyn in the pathogenesis of primary ...Acta Neuropathologica Communications 2020 8:108Molecular and clinicopathologic features of gliomas harboring NTRK fusions
Fusions involving neurotrophic tyrosine receptor kinase (NTRK) genes are detected in ≤2% of gliomas and can promote gliomagenesis. The remarkable therapeutic efficacy of TRK inhibitors, which are among the first ...Acta Neuropathologica Communications 2020 8:107Impairment in dynein-mediated nuclear translocation by BICD2 C-terminal truncation leads to neuronal migration defect and human brain malformation
During brain development, the nucleus of migrating neurons follows the centrosome and translocates into the leading process. Defects in these migratory events, which affect neuronal migration, cause lissenceph...Acta Neuropathologica Communications 2020 8:106Molecular identification of CNS NB-FOXR2, CNS EFT-CIC, CNS HGNET-MN1 and CNS HGNET-BCOR pediatric brain tumors using tumor-specific signature genes
Four molecular types of rare central nervous system (CNS) tumors have been recently identified by gene methylation profiling: CNS Neuroblastoma with FOXR2 activation (CNS NB-FOXR2), CNS Ewing Sarcoma Family Tumor...Acta Neuropathologica Communications 2020 8:105- Acta Neuropathologica Communications 2020 8:104
Complex I reductions in the nucleus basalis of Meynert in Lewy body dementia: the role of Lewy bodies
Neurons of the nucleus basalis of Meynert (nbM) are vulnerable to Lewy body formation and neuronal loss, which is thought to underlie cognitive dysfunction in Lewy body dementia (LBD). There is continued debat...Acta Neuropathologica Communications 2020 8:103High level MYCN amplification and distinct methylation signature define an aggressive subtype of spinal cord ependymoma
We report a novel group of clinically aggressive spinal cord ependymomas characterized by Grade III histology, MYCN amplification, an absence of NF2 alterations or other recurrent pathogenic mutations, and a uniq...Acta Neuropathologica Communications 2020 8:101
sábado, 29 de agosto de 2020
Acta Neuropathologica Communications | Articles
Acta Neuropathologica Communications | Articles
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