domingo, 12 de julio de 2020

Oncotype DX Breast Recurrence Score ®: A Review of Its Use in Early-Stage Breast Cancer - PubMed

Oncotype DX Breast Recurrence Score ®: A Review of Its Use in Early-Stage Breast Cancer - PubMed



Oncotype DX Breast Recurrence Score ®: A Review of Its Use in Early-Stage Breast Cancer

Affiliations 

Abstract

Oncotype DX Breast Recurrence Score® is a 21-gene prognostic and predictive assay indicated for use in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative, lymph node (LN)-negative or up to three LN-positive, early-stage breast cancer. The assay is used worldwide and is conducted at a CLIA-certified central laboratory in the USA. The 21-gene assay generates a Recurrence Score for each tumour sample, based on expression levels of 16 breast cancer-related genes, normalized to five reference genes. The Recurrence Score is a continuous variable that provides an individualized estimate of 9-year distant recurrence risk and the likelihood of adjuvant chemotherapy benefit. The 21-gene Recurrence Score assay is extensively validated in clinical studies, which are well supported by real-world registry studies. The assay informs treatment decisions and reduces adjuvant chemotherapy use in routine clinical practices, and is estimated to be cost-effective. The 21-gene Recurrence Score assay is included in all major international treatment guidelines. Currently, it is the only multigene assay validated for prediction of chemotherapy benefit, as well as for prognosis.

Similar articles

No hay comentarios:

Publicar un comentario