| J Gynecol Oncol. 2020;31:e27. English. Published online Nov 28, 2019. https://doi.org/10.3802/jgo.2020.31.e27 | |
| Copyright © 2020. Asian Society of Gynecologic Oncology, Korean Society of Gynecologic Oncology |
Yibo Dai ,* Yangyang Dong,* Yuan Cheng, Hongyi Hou, Jingyuan Wang, Zhiqi Wang, and Jianliu Wang | |
| Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, China. | |
| Correspondence to Zhiqi Wang. Department of Obstetrics and Gynecology, Peking University People's Hospital, No. 11, Xizhimen South Street, Xicheng District, Beijing 100044, China. *Yibo Dai and Yangyang Dong contributed equally to this work as co-first author. | |
| Received April 19, 2019; Revised August 24, 2019; Accepted October 16, 2019. | |
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by- | |
Abstract | |
Objective This study aims to analyze factors associated with lymphovascular space invasion (LVSI) and evaluate the prognostic significance of LVSI in Chinese endometrioid endometrial cancer (EEC) patients. Methods Five-hundred eighty-four EEC patients undergoing surgery in our center from 2006 to 2016 were selected for analysis. Univariate analysis and multivariate logistic regression were used to examine relevant factors of LVSI. To evaluate the prognostic role of LVSI, survival analyses were conducted. In survival analyses, both multivariate Cox regression and propensity score matching were used to control the confounders. Results The incidence of LVSI was 12.16% (71/584). Diabetes history (p=0.021), lymph node metastasis (p=0.005), deep myometrial invasion (p<0.001) and negative PR expression (p=0.007) were independently associated with LVSI. Both Kaplan-Meier method and univariate Cox regressions showed LVSI negative and positive cases had similar tumor-specific survival (TSS) and disease-free survival (DFS). After adjusting for the influence of adjuvant therapy and other clinicopathological factors with multivariate Cox regressions, LVSI still could not bring additional survival risk to the patients (p=0.280 and p=0.650 for TSS and DFS, respectively). This result was verified by Kaplan-Meier survival analyses after propensity score matching (p=0.234 and p=0.765 for TSS and DFS, respectively). Conclusion LVSI does not significantly compromise the survival outcome of Chinese EEC patients. | |
Keywords: Endometrial Neoplasms; Lymphovascular Space Invasion; Recurrence; Survival | |
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