PET-CT has low specificity for mediastinal staging of non-small-cell lung cancer in an endemic area for tuberculosis: a diagnostic test study (LACOG 0114)

Gustavo WerutskyEmail author,
Bruno Hochhegger,
José Antônio Lopes de Figueiredo Pinto,
Jeovany Martínez-Mesa,
Mara Lise Zanini,
Eduardo Herz Berdichevski,
Eduardo Vilas,
Vinícius Duval da Silva,
Maria Teresa Ruiz Tsukazan,
Arthur Vieira,
Leandro Genehr Fritscher,
Louise Hartmann,
Marcos Alba,
Guilherme Sartori,
Cristina Matushita,
Vanessa Bortolotto,
Rayssa Ruszkowski do Amaral,
Luís Carlos Anflor Junior,
Facundo Zaffaroni,
Carlos H. Barrios,
Márcio Debiasi and
Carlos Cezar Frietscher

BMC Cancer201919:5

https://doi.org/10.1186/s12885-018-5233-5

Received: 5 May 2018
Accepted: 19 December 2018
Published: 3 January 2019

Open Peer Review reports

Abstract

Background

The present study aims to assess the performance of 18F-FDG PET-CT on mediastinal staging of non-small cell lung cancer (NSCLC) in a location with endemic granulomatous infectious disease.

Methods

Diagnostic test study including patients aged 18 years or older with operable stage I-III NSCLC and indication for a mediastinal lymph node biopsy. All patients underwent a 18F-FDG PET-scan before invasive mediastinal staging, either through mediastinoscopy or thoracotomy, which was considered the gold-standard. Surgeons and pathologists were blinded for scan results. Primary endpoint was to evaluate sensitivity, specificity and positive and negative predictive values of PET-CT with images acquired in the 1st hour of the exam protocol, using predefined cutoffs of maximal SUV, on per-patient basis.

Results

Overall, 85 patients with operable NSCLC underwent PET-CT scan followed by invasive mediastinal staging. Mean age was 65 years, 49 patients were male and 68 were white. One patient presented with active tuberculosis and none had HIV infection. Using any SUV_max > 0 as qualitative criteria for positivity, sensitivity and specificity were 0.87 and 0.45, respectively. Nevertheless, even when the highest SUV cut-off was used (SUV_max ≥5), specificity remained low (0.79), with an estimated positive predictive value of 54%.

Conclusions

Our findings are in line with the most recent publications and guidelines, which recommend that PET-CT must not be solely used as a tool to mediastinal staging, even in a region with high burden of tuberculosis.