CIENCIASMEDICASNEWS: Computational-based Approaches to Protein Function Prediction

martes, 8 de enero de 2019

Computational-based Approaches to Protein Function Prediction

	January 8, 2019
	Biochemistry
	The latest biochemistry news from AZoNetwork

Computational-basedApproaches to Protein Function Prediction

The most effective way of determining protein structure from sequence alone is by using computational methods. This is based on direct comparison of the unknown protein sequence with the sequence of a protein whose structure is known.

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	A Story of Innovative Molecules: From Machines to Cyclic Compounds 2016 Nobel Laureate in Chemistry Fraser Stoddart outlines his research involving mechanically interlocked molecules and molecular machines, and introduces the work of some of the students in his lab, to be discussed at Pittcon 2018.

	Predicting Protein Function from DNA Sequences Identifying the function of a protein from its sequence alone is possible using a genetics-based approach. The principle of this approach is coarse; it involves detecting the presence of mRNA encoding a protein of unknown function.

	Interval of time to biochemical failure could be used as surrogate endpoint for prostate cancer An analysis of the NRG Oncology clinical trial NRG-RTOG 9202 showed that the interval of time to biochemical failure, or the time it takes for previously treated cancer to return as indicated by prostate specific antigen rise, could be used as a surrogate endpoint for locally advanced prostate cancer.

	Scientists fix flawed plant genes, make plants grow 40% larger They say the development could be applied to increase the yield of other important crops, as a way of boosting food productivity for a growing population in the face of climate change. The research was published today in the journal Science.

	Phage Display: Applications in Research Phage display begins by incorporating the protein of interest into the external surface of the bacteriophage. This is done by splicing the segment of normal DNA that encodes for the protein into the DNA sequence of the bacteriophage which encodes for the phage coat proteins.

	Researchers identify promising new therapeutic target for Parkinson’s A study led by researchers at Brigham and Women’s Hospital and Harvard Medical School has shed light on the role fatty acids play in Parkinson’s disease and pointed towards an enzyme as a potential therapeutic target for the disease.