Alzheimer's Research & TherapyAlcohol use and dementia: a systematic scoping review
Alzheimer's Research & Therapy201911:1
© The Author(s). 2019
- Published: 5 January 2019
Abstract
Background
Alcohol use has been identified as a risk factor for dementia and cognitive decline. However, some patterns of drinking have been associated with beneficial effects.
Methods and Results
To clarify the relationship between alcohol use and dementia, we conducted a scoping review based on a systematic search of systematic reviews published from January 2000 to October 2017 by using Medline, Embase, and PsycINFO. Overall, 28 systematic reviews were identified: 20 on the associations between the level of alcohol use and the incidence of cognitive impairment/dementia, six on the associations between dimensions of alcohol use and specific brain functions, and two on induced dementias. Although causality could not be established, light to moderate alcohol use in middle to late adulthood was associated with a decreased risk of cognitive impairment and dementia. Heavy alcohol use was associated with changes in brain structures, cognitive impairments, and an increased risk of all types of dementia.
Conclusion
Reducing heavy alcohol use may be an effective dementia prevention strategy.
Keywords
- Dementia
- Alcohol
- Risk
- Systematic review
- Alzheimer’s disease
- Vascular dementia
- Brain function
- Brain volumetrics
- Cognition
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