MicroRNAs are inappropriate for characterising hearing impairment in mitochondrial disorders | Orphanet Journal of Rare Diseases | Full Text

MicroRNAs are inappropriate for characterising hearing impairment in mitochondrial disorders | Orphanet Journal of Rare Diseases | Full Text

Orphanet Journal of Rare Diseases

MicroRNAs are inappropriate for characterising hearing impairment in mitochondrial disorders

• Josef FinstererEmail author and
 
• Sinda Zarrouk-Mahjoub

Orphanet Journal of Rare Diseases201813:87

https://doi.org/10.1186/s13023-018-0831-5

©  The Author(s). 2018

Received: 6 March 2018

Accepted: 23 May 2018

Published: 31 May 2018

Keywords

MitochondrialHereditary neuropathyPhenotypeGenotypeMultisystem diseaseLactic acidosis

Letter to the Editor

We read with interest the review by Di Stadio et al. about microRNAs (miRs) for the diagnostic work-up of hypoacusis in MELAS [1]. It was suspected that miR-34a, miR-29b, miR-299-3p, and miR-431 can be useful as biomarkers for detecting and characterising inner ear involvement in MELAS [1]. We have the following comments and concerns.