Orphanet Journal of Rare Diseases
MicroRNAs are inappropriate for characterising hearing impairment in mitochondrial disorders
Orphanet Journal of Rare Diseases201813:87
© The Author(s). 2018
Published: 31 May 2018
MitochondrialHereditary neuropathyPhenotypeGenotypeMultisystem diseaseLactic acidosis
Letter to the Editor
We read with interest the review by Di Stadio et al. about microRNAs (miRs) for the diagnostic work-up of hypoacusis in MELAS . It was suspected that miR-34a, miR-29b, miR-299-3p, and miR-431 can be useful as biomarkers for detecting and characterising inner ear involvement in MELAS . We have the following comments and concerns.