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Featured video: Another mechanism for the initiation and progression of Parkinson's disease

 

A research team in the USA and China identifies a potential disease mechanism in the initiation and development of Parkinson’s disease. 

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1. Content Type:Research

     |  11 June 2018

   Sequential stages and distribution patterns of aging-related tau astrogliopathy (ARTAG) in the human brain

   Authors:Gabor G. Kovacs, Sharon X. Xie, John L. Robinson, Edward B. Lee, Douglas H. Smith, Theresa Schuck, Virginia M.-Y. Lee and John Q. Trojanowski
2. Content Type:Research

     |  11 June 2018

   Network-based analysis of oligodendrogliomas predicts novel cancer gene candidates within the region of the 1p/19q co-deletion

   Authors:Josef Gladitz, Barbara Klink and Michael Seifert
3. Content Type:Research

     |  7 June 2018

   Proteomic analysis of Medulloblastoma reveals functional biology with translational potential

   Authors:Samuel Rivero-Hinojosa, Ling San Lau, Mojca Stampar, Jerome Staal, Huizhen Zhang, Heather Gordish-Dressman, Paul A. Northcott, Stefan M. Pfister, Michael D. Taylor, Kristy J. Brown and Brian R. Rood
4. Content Type:Research

     |  7 June 2018

   The genetic landscape of ganglioglioma

   Authors:Melike Pekmezci, Javier E. Villanueva-Meyer, Benjamin Goode, Jessica Van Ziffle, Courtney Onodera, James P. Grenert, Boris C. Bastian, Gabriel Chamyan, Ossama M. Maher, Ziad Khatib, Bette K. Kleinschmidt-DeMasters, David Samuel, Sabine Mueller, Anuradha Banerjee, Jennifer L. Clarke, Tabitha Cooney…
5. Content Type:Research

     |  4 June 2018

   Proteomics analysis identifies new markers associated with capillary cerebral amyloid angiopathy in Alzheimer’s disease

   Authors:David C. Hondius, Kristel N. Eigenhuis, Tjado H. J. Morrema, Roel C. van der Schors, Pim van Nierop, Marianna Bugiani, Ka Wan Li, Jeroen J. M. Hoozemans, August B. Smit and Annemieke J. M. Rozemuller

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Featured article: Transmission of α-synuclein-containing erythrocyte-derived extracellular vesicles across the blood-brain barrier via adsorptive mediated transcytosis: another mechanism for initiation and progression of Parkinson’s disease?

Professor Zhang et al investigate the mechanism of extracellular vesicle transmission across the blood-brain barrier as it relates to Parkinson's Disease.

Featured article: Novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson’s disease

Dr. Finkelstein et al report the preclinical characterization of PBT434, a novel quinazolinone compound bearing a moderate affinity metal-binding motif, which is in development for Parkinsonian conditions.